Literature DB >> 5693925

Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. 3. Analysis of mechanism.

N H Ruddle, B H Waksman.   

Abstract

The cytopathic effect of lymph node cells from tuberculin-sensitized rats on rat embryo fibroblasts in the presence of PPD was not enhanced by admixture of normal (nonsensitized) lymph node cells. Preincubation studies showed that this in vitro response is initiated by the reaction of lymphocytes with specific antigen, beginning within 30 min, rather than uptake of antigen by the fibroblasts. The supernatant fluids from suspensions of sensitized cells incubated with PPD for 17 hr or more possessed cytotoxic activity. The target fibroblasts showed a marked increase in acid phosphatase content within 48 hr after the addition of sensitized lymph node cells and antigen.

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Year:  1968        PMID： 5693925      PMCID： PMC2138574          DOI： 10.1084/jem.128.6.1267

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  31 in total

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Journal:  J Allergy       Date:  1963 Jul-Aug

3.  GAMMA-GLOBULIN PRODUCTION BY HUMAN LYMPHOCYTES IN VITRO.

Authors:  F BACH; K HIRSCHHORN
Journal:  Exp Cell Res       Date:  1963-12       Impact factor: 3.905

4.  IN VITRO DEMONSTRATION OF ANTI-OVALBUMIN SPECIFICITY OF LYMPH NODE CELLS IN DELAYED TYPE HYPERSENSITIVITY.

Authors:  C STEFFEN; M ROSAK
Journal:  J Immunol       Date:  1963-03       Impact factor: 5.422

5.  Studies on the mechanism of delayed type hypersensitivity in tissue cultures. IX. The effect of glucose concentration on the reaction of delayed type hypersensitivity in tissue cultures.

Authors:  J Svejcar; J Johanovský; J Pekárek
Journal:  Z Immunitatsforsch Allerg Klin Immunol       Date:  1967-04

6.  Lymphocyte RNA metabolism. Comparison between antigen and phytohaemagglutinin stimulation.

Authors:  H L Cooper; A D Rubin
Journal:  Lancet       Date:  1965-10-09       Impact factor: 79.321

7.  Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

Authors:  B R Bloom; B Bennett
Journal:  Science       Date:  1966-07-01       Impact factor: 47.728

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Authors:  S SELL; P G GELL
Journal:  J Exp Med       Date:  1965-08-01       Impact factor: 14.307

9.  Suppression of delayed hypersensitivity in vitro by inhibition of protein synthesis.

Authors:  J R David
Journal:  J Exp Med       Date:  1965-12-01       Impact factor: 14.307

10.  Cytotoxicity mediated by soluble antigen and lymphocytes in delayed hypersensitivity. I. Characterization of the phenomenon.

Authors:  N H Ruddle; B H Waksman
Journal:  J Exp Med       Date:  1968-12-01       Impact factor: 14.307
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8.  Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

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9.  Lymphocyte transformation and production of a human mononuclear leucocyte chemotactic factor in patients with Hodgkin's disease.

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10.  Cytotoxicity of concanavalin A-activated hamster lymphocytes.

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