Literature DB >> 569363

Chemotactic responses of tumor cells to products of resorbing bone.

W Orr, J Varani, M K Gondex, P A Ward, G R Mundy.   

Abstract

To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factoor is released by a variety of agents that induce resorption of bone.

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Year:  1979        PMID： 569363     DOI： 10.1126/science.569363

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  26 in total

1.  Tumor products and the hypercalcemia of malignancy.

Authors:  G R Mundy; K J Ibbotson; S M D'Souza
Journal:  J Clin Invest       Date:  1985-08       Impact factor: 14.808

2.  Signal transduction for chemotaxis and haptotaxis by matrix molecules in tumor cells.

Authors:  S Aznavoorian; M L Stracke; H Krutzsch; E Schiffmann; L A Liotta
Journal:  J Cell Biol       Date:  1990-04       Impact factor: 10.539

3.  In vitro effects of bone- and platelet-derived transforming growth factor-beta on the growth of Walker 256 carcinosarcoma cells.

Authors:  W Millar-Book; F W Orr; G Singh
Journal:  Clin Exp Metastasis       Date:  1990 Nov-Dec       Impact factor: 5.150

Review 4.  The role of bisphosphonates as adjuvant therapy for breast cancer.

Authors:  J R Gralow
Journal:  Curr Oncol Rep       Date:  2001-11       Impact factor: 5.075

Review 5.  Tumor invasion and host extracellular matrix.

Authors:  B U Pauli; D E Schwartz; E J Thonar; K E Kuettner
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

Review 6.  Vitamin D, phagocyte differentiation and immune function.

Authors:  T K Gray; M S Cohen
Journal:  Surv Immunol Res       Date:  1985

Review 7.  The role of cell adhesion proteins--laminin and fibronectin--in the movement of malignant and metastatic cells.

Authors:  J B McCarthy; M L Basara; S L Palm; D F Sas; L T Furcht
Journal:  Cancer Metastasis Rev       Date:  1985       Impact factor: 9.264

8.  The chemotactic response of tumor cells. A model for cancer metastasis.

Authors:  W C Lam; E J Delikatny; F W Orr; J Wass; J Varani; P A Ward
Journal:  Am J Pathol       Date:  1981-07       Impact factor: 4.307

9.  Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in vitro.

Authors:  J B McCarthy; L T Furcht
Journal:  J Cell Biol       Date:  1984-04       Impact factor: 10.539

10.  Generation of a complement-derived chemotactic factor for tumor cells in experimentally induced peritoneal exudates and its effect on the local metastasis of circulating tumor cells.

Authors:  F W Orr; S Mokashi; J Delikatny
Journal:  Am J Pathol       Date:  1982-07       Impact factor: 4.307
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