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Literature DB >> 569281

Effect of divalent cations on acetylcholine release from cardiac parasympathetic nerve endings.

Abstract

The influence of several divalent cations on acetylcholine (ACh) release from vagus nerve terminals was studied in quiescent guinea-pig auricles. ACh release was induced by stimulus trains subthreshold for excitation of atrial cells. The ACh released evoked a hyperpolarization of the atrial cell membrane. Changes in ACh sensitivity of the atrial cell membrane were tested by application of ACh-containing solutions. ACh release increased with the external Ca concentration. External Sr maintained the ACh release in 'Ca-free' media. However, Sr ions were less effective than Ca ions. External Mg acted as a weak inhibitor of the stimulus evoked ACh release, whereas Co and Mn ions exerted a strong inhibition.

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Year: 1978 PMID： 569281 DOI： 10.1007/bf00584374

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

24 in total

2. Facilitation of acetylcholine release from cardiac parasympathetic nerve endings. Effect of stimulation pattern and Mn ions.

Authors: M Bechem; H G Glitsch; L Pott
Journal: Pflugers Arch Date: 1981-08 Impact factor: 3.657

2 in total

Effect of divalent cations on acetylcholine release from cardiac parasympathetic nerve endings.

1. Production of membrane potential changes in the frog's heart by inhibitory nerve impulses.

2. The nature of the antagonism between calcium and magnesium ions at the neuromuscular junction.

3. The Electrical changes in the Quiescent Cardiac Muscle which accompany Stimulation of the Vagus Nerve.

4. Effects of Na and K ions on the active Na transport in guinea-pig auricles.

5. Modification by calcium of the release of autonomic mediators in the isolated sinoatrial node.

6. Interaction between Na, Ca, Mg, and vagal stimulation in the S-A node of the rabbit.

7. The action of cobalt ions on neuromuscular transmission in the frog.

8. Effects of acetylcholine and parasympathetic nerve stimulation on membrane potential in quiescent guinea-pig atria.

9. Modification of transmitter release by ions which prolong the presynaptic action potential.

10. On the mechanism by which calcium and magnesium affect the release of transmitter by nerve impulses.

1. On the time course of the acetylcholine-induced hyperpolarization in quiescent guinea-pig atria.

2. Facilitation of acetylcholine release from cardiac parasympathetic nerve endings. Effect of stimulation pattern and Mn ions.