Literature DB >> 568888

Characteristics of the chemotactic response of neoplastic cells to a factor derived from the fifth component of complement.

W Orr, J Varani, P A Ward.   

Abstract

Chemotactic factors for malignant neoplastic cells can be generated from either the fifth component of complement or from leukotactic fractions obtained from zymosanactivated serum. Digestion of the fifth component of complement by trypsin initially produced leukotactic activity, but as digestion continues, leukotactic activity is lost and tumor cell chemotactic activity is generated. Separation of the leukotactic activity is lost and tumor cell chemotactic activity is generated. Separation of the leukotactic activity and tumor cell chemotactic activity can be accomplished by gel filtration or isoelectric focusing. Gel filtration indicates that the tumor cell chemotactic factor has a molecular weight of approximately 8000 daltons. Tumor cell chemotactic activity can be generated by trypsinizing the leukotactic fractions isolated by isoelectric focusing. The responses of cultured Walker tumor cells or of Walker ascites tumor cells are dose-dependent and truly chemotactic. Cells from a murine malignant lymphoma do not respond to the complement-derived chemotactic factor for tumor cells, indicating that not all malignant cells share this functional property.

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Year:  1978        PMID： 568888      PMCID： PMC2018385     

Source DB:  PubMed          Journal:  Am J Pathol        ISSN： 0002-9440            Impact factor:   4.307


  14 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1.

Authors:  R Snyderman; M C Pike; D G Fischer; H S Koren
Journal:  J Immunol       Date:  1977-12       Impact factor: 5.422

3.  Studies on the mechanisms of invasion in cancer. II. In vivo effects of a factor chemotactic for cancer cells.

Authors:  T Ozaki; K Yoshida; K Ushijima; H Hayashi
Journal:  Int J Cancer       Date:  1971-01-15       Impact factor: 7.396

4.  Studies on the mechanisms of invasion in cancer. I. Isolation and purification of a factor chemotactic for cancer cells.

Authors:  K Yoshida; T Ozaki; K Ushijima; H Hayashi
Journal:  Int J Cancer       Date:  1970-07-15       Impact factor: 7.396

5.  Bacterial factors chemotactic for polymorphonuclear leukocytes.

Authors:  P A Ward; I H Lepow; L J Newman
Journal:  Am J Pathol       Date:  1968-04       Impact factor: 4.307

6.  Additional studies on human C5: development of a modified purification method and characterization of the purified product by polyacrylamide gel electrophoresis.

Authors:  U R Nilsson; R H Tomar; F B Taylor
Journal:  Immunochemistry       Date:  1972-07

7.  Two distinct chemotactic factor inactivators in human serum.

Authors:  G Till; P A Ward
Journal:  J Immunol       Date:  1975-02       Impact factor: 5.422

8.  A comparison of the migration patterns of normal and malignant cells in two assay systems.

Authors:  J Varani; W Orr; P A Ward
Journal:  Am J Pathol       Date:  1978-01       Impact factor: 4.307

9.  Estimation of the molecular weights of proteins by Sephadex gel-filtration.

Authors:  P Andrews
Journal:  Biochem J       Date:  1964-05       Impact factor: 3.766

10.  Interactions between rabbit polymorphonuclear leucocytes and staphylococci.

Authors:  Z A COHN; S I MORSE
Journal:  J Exp Med       Date:  1959-09-01       Impact factor: 14.307
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  15 in total

Review 1.  PMN adhesion and extravasation as a paradigm for tumor cell dissemination.

Authors:  C W Smith; D C Anderson
Journal:  Cancer Metastasis Rev       Date:  1991-05       Impact factor: 9.264

2.  Generation and characterization of a neutrophil-derived inhibitor of fibroblast chemotaxis.

Authors:  H Mensing; B M Czarnetzki
Journal:  Arch Dermatol Res       Date:  1986       Impact factor: 3.017

3.  Digestion of the fifth component of complement by leukocyte enzymes. Sequential generation of chemotactic activities for leukocytes and for tumor cells.

Authors:  F W Orr; J Varani; D L Kreutzer; R M Senior; P A Ward
Journal:  Am J Pathol       Date:  1979-01       Impact factor: 4.307

4.  Chemotactic factor for tumor cells derived from the C5a fragment of complement component C5.

Authors:  W Orr; S H Phan; J Varani; P A Ward; D L Kreutzer; R O Webster; P M Henson
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

Review 5.  Tumor invasion and host extracellular matrix.

Authors:  B U Pauli; D E Schwartz; E J Thonar; K E Kuettner
Journal:  Cancer Metastasis Rev       Date:  1983       Impact factor: 9.264

6.  Partial characterization of a bone-derived chemotactic factor for tumor cells.

Authors:  F W Orr; J Varani; M D Gondek; P A Ward; G R Mundy
Journal:  Am J Pathol       Date:  1980-04       Impact factor: 4.307

7.  The chemotactic response of tumor cells. A model for cancer metastasis.

Authors:  W C Lam; E J Delikatny; F W Orr; J Wass; J Varani; P A Ward
Journal:  Am J Pathol       Date:  1981-07       Impact factor: 4.307

8.  Isolation of three separate anaphylatoxins from complement-activated human serum.

Authors:  T E Hugli; C Gerard; M Kawahara; M E Scheetz; R Barton; S Briggs; G Koppel; S Russell
Journal:  Mol Cell Biochem       Date:  1981-12-04       Impact factor: 3.396

9.  Platelet factors induce chemotactic migration of murine mammary adenocarcinoma cells with different metastatic capabilities.

Authors:  M A Sarach; R A Rovasio; A R Eynard
Journal:  Int J Exp Pathol       Date:  1993-10       Impact factor: 1.925

10.  Generation of a complement-derived chemotactic factor for tumor cells in experimentally induced peritoneal exudates and its effect on the local metastasis of circulating tumor cells.

Authors:  F W Orr; S Mokashi; J Delikatny
Journal:  Am J Pathol       Date:  1982-07       Impact factor: 4.307
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