Literature DB >> 5687584

Antagonism of reserpine-induced emesis in pigeons: a screening method for antidepressant activity.

K N Dhawan, G P Gupta, B P Jaju.   

Abstract

1. Various antidepressant drugs and procedures have been studied against reserpine-induced emesis in pigeons.2. Electroconvulsions, pentylenetetrazol and a non-hydrazide monoamine oxidase inhibitor (pargyline) block reserpine emesis.3. It is suggested that reserpine-induced emesis in pigeons provides a simple and reliable method for studying anti-reserpine activity, and the compounds effective in antagonizing this emetic response are likely to have antidepressant property.

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Year:  1968        PMID： 5687584      PMCID： PMC1703341          DOI： 10.1111/j.1476-5381.1968.tb07047.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  6 in total

1.  The anti-reserpine effects of certain centrally-acting agents.

Authors:  G CHEN; B BOHNER
Journal:  J Pharmacol Exp Ther       Date:  1961-02       Impact factor: 4.030

2.  Blockade of reserpine emesis in pigeons.

Authors:  G P GUPTA; B N DHAWAN
Journal:  Arch Int Pharmacodyn Ther       Date:  1960-11-01

3.  Demonstration of anti-depressant or stimulant properties of imipramine in experimental animals.

Authors:  D R MAXWELL; H T PALMER
Journal:  Nature       Date:  1961-07-01       Impact factor: 49.962

4.  Bioassay of Rauwolfia roots and alkaloids.

Authors:  B RUBIN; M H MALONE; M H WAUGH; J C BURKE
Journal:  J Pharmacol Exp Ther       Date:  1957-06       Impact factor: 4.030

5.  Assay of reserpine based on emesis in pigeons.

Authors:  A E EARL; R L WINTERS; C M SCHNEIDER
Journal:  J Pharmacol Exp Ther       Date:  1955-09       Impact factor: 4.030

6.  Studies on the blood glucose and pancreatic islets of lizards.

Authors:  M R MILLER; D H WURSTER
Journal:  Endocrinology       Date:  1956-01       Impact factor: 4.736
  6 in total

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