Literature DB >> 5685874

Biosynthesis of cyclopropyl long-chain fatty acids from cyclopropanecarboxylic acid by mammalian tissues in vitro.

W G Duncombe, T J Rising.   

Abstract

1. Radioactivity from cyclopropane[(14)C]carboxylic acid is incorporated into fatty acids in vitro by rat and guinea-pig adipose tissue, by rat liver slices and by the supernatant fraction of rat liver homogenate. 2. The labelled acids are different from endogenous straight-chain fatty acids, and evidence is produced that they consist of a cyclopropyl ring in the omega-position, the remainder of the chain being built up from C(2) units (not derived from cyclopropanecarboxylic acid) in the normal way via the malonate pathway. 3. It is suggested that these unnatural acids have some metabolic effect related to the hypoglycaemic action of cyclopropanecarboxylic acid.

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Year:  1968        PMID： 5685874      PMCID： PMC1186838          DOI： 10.1042/bj1090449

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  19 in total

1.  THE DETERMINATION OF THE FATTY ACID COMPOSITION OF SERUM LIPIDS SEPARATED BY THIN-LAYER CHROMATOGRAPHY; AND A COMPARISON WITH COLUMN CHROMATOGRAPHY.

Authors:  D E BOWYER; W M LEAT; A N HOWARD; G A GRESHAM
Journal:  Biochim Biophys Acta       Date:  1963-08-27

Review 2.  LIPID METABOLISM.

Authors:  P R VAGELOS
Journal:  Annu Rev Biochem       Date:  1964       Impact factor: 23.643

3.  The effect of some cofactors on the synthesis of fatty acids and cholesterol in cell-fre preparations of rat liver.

Authors:  K FLETCHER; N B MYANT
Journal:  J Physiol       Date:  1961-03       Impact factor: 5.182

4.  A simple device for the rapid routine liberation and trapping of C-14-02 for scintillation counting.

Authors:  G MOSS
Journal:  Int J Appl Radiat Isot       Date:  1961-08

5.  cis-9,10-Methylene hexadecanoic acid from the phospholipids of Escherichia coli.

Authors:  T KANESHIRO; A G MARR
Journal:  J Biol Chem       Date:  1961-10       Impact factor: 5.157

6.  Cyclopropane ring blosynthesis.

Authors:  T Y LIU; K HOFMANN
Journal:  Biochemistry       Date:  1962-01       Impact factor: 3.162

7.  The effect of pent-4-enoic acid and some simple related compounds on the oxidation of fatty acids by rat-liver mitochondria.

Authors:  A E Senior; H S Sherratt
Journal:  Biochem J       Date:  1967-09       Impact factor: 3.857

8.  Metabolic effects of hypoglycin and methylenecyclopropaneacetic acid.

Authors:  C Von Holt; M Von Holt; H Böhm
Journal:  Biochim Biophys Acta       Date:  1966-08-03

9.  Fatty acid synthesis in rat adipose tissue. Tracer concentration effects in vitro.

Authors:  W G Duncombe
Journal:  Biochem J       Date:  1968-01       Impact factor: 3.857

10.  Ring location in cyclopropane fatty acid esters by a mass spectrometric method.

Authors:  J A McCloskey; J H Law
Journal:  Lipids       Date:  1967-05       Impact factor: 1.880
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  2 in total

1.  Biochemical effects of the hypoglycaemic compound pent-4-enoic acid and related non-hypoglycaemic fatty acids. Effects of the free acids and their carnitine esters on coenzyme A-dependent oxidations in rat liver mitochondria.

Authors:  P C Holland; H S Sherratt
Journal:  Biochem J       Date:  1973-09       Impact factor: 3.857

Review 2.  Paracetamol use during pregnancy - a call for precautionary action.

Authors:  Ann Z Bauer; Shanna H Swan; David Kriebel; Zeyan Liew; Hugh S Taylor; Carl-Gustaf Bornehag; Anderson M Andrade; Jørn Olsen; Rigmor H Jensen; Rod T Mitchell; Niels E Skakkebaek; Bernard Jégou; David M Kristensen
Journal:  Nat Rev Endocrinol       Date:  2021-09-23       Impact factor: 43.330
  2 in total

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