Literature DB >> 567843

Genetically determined sex-reversal in 46,XY humans.

J German, J L Simpson, R S Chaganti, R L Summitt, L B Reid, I R Merkatz.   

Abstract

Evidence is presented for the existence of a gene, probably on the X chromosome, which prevents testis differentiation when present in 46,XY human embryos. Affected 46,XY women are not completely normal because of premature ovarian involution, as a result of which they have "streak gonads" similiar to those of 45,X women.

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Year:  1978        PMID： 567843     DOI： 10.1126/science.567843

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  25 in total

1.  XY gonadal dysgenesis and the H-Y antigen. Report on 12 cases.

Authors:  U Wolf
Journal:  Hum Genet       Date:  1979-04-05       Impact factor: 4.132

Review 2.  Molecular determinants of sexual differentiation.

Authors:  J S Wiener; M Marcelli; D J Lamb
Journal:  World J Urol       Date:  1996       Impact factor: 4.226

3.  Molecular analysis of 46,XY females and regional assignment of a new Y-chromosome-specific probe.

Authors:  M A Cantrell; J N Bicknell; R A Pagon; D C Page; D C Walker; H M Saal; A B Zinn; C M Disteche
Journal:  Hum Genet       Date:  1989-08       Impact factor: 4.132

4.  Heteromorphic X chromosomes in 46,XX males: evidence for the involvement of X-Y interchange.

Authors:  H J Evans; K E Buckton; G Spowart; A D Carothers
Journal:  Hum Genet       Date:  1979-05-23       Impact factor: 4.132

5.  Antenatal prediction of sex.

Authors: 
Journal:  Br Med J       Date:  1979-09-29

6.  Gonadal dimorphism explained as a dosage effect of a locus on the sex chromosomes, the gonad-differentiation locus (GDL).

Authors:  J German
Journal:  Am J Hum Genet       Date:  1988-03       Impact factor: 11.025

7.  Female phenotype and multiple abnormalities in sibs with a Y chromosome and partial X chromosome duplication: H--Y antigen and Xg blood group findings.

Authors:  R Bernstein; T Jenkins; B Dawson; J Wagner; G Dewald; G C Koo; S S Wachtel
Journal:  J Med Genet       Date:  1980-08       Impact factor: 6.318

8.  Absence of H-Y antigen in a case of sporadic pure gonadal dysgenesis.

Authors:  C Boucekkine; M Benmiloud; B Himeur; A Chouiter; M Bachammar
Journal:  J Endocrinol Invest       Date:  1984-06       Impact factor: 4.256

9.  H-Y antigen in X,i(Xq) gonadal dysgenesis: evidence of X-linked genes in testicular differentiation.

Authors:  S S Wachtel; G C Koo; W R Breg; M Genel
Journal:  Hum Genet       Date:  1980       Impact factor: 4.132

10.  Report of fertility in a woman with a predominantly 46,XY karyotype in a family with multiple disorders of sexual development.

Authors:  Miroslav Dumic; Karen Lin-Su; Natasha I Leibel; Srecko Ciglar; Giovanna Vinci; Ruzica Lasan; Saroj Nimkarn; Jean D Wilson; Ken McElreavey; Maria I New
Journal:  J Clin Endocrinol Metab       Date:  2007-11-13       Impact factor: 5.958
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