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Literature DB >> 5676528

Effects of guanidine derivatives on mitochondrial function. II. Reversal of guanidine-derivative inhibiton by free fatty acids.

Abstract

Long chain free fatty acids interfere with the inhibitory action of phenethylbiguanide and related compounds on mitochondrial respiration in vitro. This interference depends on binding of fatty acids to mitochondria and diminishes with decreasing chain length. Reversal of guanidine-derivative inhibition by fatty acids differs from that caused by dinitrophenol in that the effect of fatty acid is achieved without alteration in coupling or respiratory control. The binding of phenethylbiguanide to mitochondria is inhibited by both fatty acid and dinitrophenol. Serum albumin potentiates the inhibitory potency of guanidine derivatives, probably by removing endogenous mitochondrial free fatty acids.

Entities: Chemical

Mesh：

Substances：

Year: 1968 PMID： 5676528 PMCID： PMC297398 DOI： 10.1172/JCI105919

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

24 in total

1. The respiratory chain and oxidative phosphorylation.

Authors: B CHANCE; G R WILLIAMS
Journal: Adv Enzymol Relat Subj Biochem Date: 1956

2. The effect of long-chain fatty acids on orthophosphate-adenosine 5'-triphosphate exchange activity associated with oxidative phosphorylation.

Authors: A B Falcone; R L Mao
Journal: Biochim Biophys Acta Date: 1965-08-24

3. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

Authors: J R Williamson; R A Kreisberg; P W Felts
Journal: Proc Natl Acad Sci U S A Date: 1966-07 Impact factor: 11.205

4. Paths of carbon in gluconeogenesis and lipogenesis: the role of mitochondria in supplying precursors of phosphoenolpyruvate.

Authors: H A Lardy; V Paetkau; P Walter
Journal: Proc Natl Acad Sci U S A Date: 1965-06 Impact factor: 11.205

5. [The effect of N1, n-butylbiguanide on the metabolism of isolated perfused livers of normal and alloxan-diabetic ketotic rats].

Authors: H D Söling; D Moshagen; E Skutella; P Kneer; W Creutzfeldt
Journal: Diabetologia Date: 1967-06 Impact factor: 10.122

6. On the mechanism of fatty acid inhibition of mitochondrial metabolism.

Authors: L Vázquez-Colón; F D Ziegler; W B Elliott
Journal: Biochemistry Date: 1966-04 Impact factor: 3.162

7. The effect of malate and other dicarboxylic acids on mitochondrial isocitrate metabolism.

Authors: S M Ferguson; G R Williams
Journal: J Biol Chem Date: 1966-08-25 Impact factor: 5.157

8. The effects of histones and other polycations on cellular energetics. IV. Further studies on the stimulation of mitochondrial oxygen consumption.

Authors: C L Johnson; B Safer; A Schwartz
Journal: J Biol Chem Date: 1966-10-10 Impact factor: 5.157

7. Effects of guanidine derivatives on mitochondrial function. I. Phenethylbiguanide inhibition of respiration in mitochondria from guinea pig and rat tissues.

Authors: F Davidoff
Journal: J Clin Invest Date: 1968-10 Impact factor: 14.808

Review 8. A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate.

Authors: Hartmut Glossmann; Norbert Reider
Journal: Dermatoendocrinol Date: 2013-04-01

8 in total

Effects of guanidine derivatives on mitochondrial function. II. Reversal of guanidine-derivative inhibiton by free fatty acids.

1. The respiratory chain and oxidative phosphorylation.

2. The effect of long-chain fatty acids on orthophosphate-adenosine 5'-triphosphate exchange activity associated with oxidative phosphorylation.

3. Mechanism for the stimulation of gluconeogenesis by fatty acids in perfused rat liver.

4. Paths of carbon in gluconeogenesis and lipogenesis: the role of mitochondria in supplying precursors of phosphoenolpyruvate.

5. [The effect of N1, n-butylbiguanide on the metabolism of isolated perfused livers of normal and alloxan-diabetic ketotic rats].

6. On the mechanism of fatty acid inhibition of mitochondrial metabolism.

7. The effect of malate and other dicarboxylic acids on mitochondrial isocitrate metabolism.

8. The effects of histones and other polycations on cellular energetics. IV. Further studies on the stimulation of mitochondrial oxygen consumption.

9. The control of rat-heart phosphofructokinase by citrate and other regulators.

10. 2,4-DINITROPHENOL: LACK OF INTERACTION WITH HIGH-ENERGY INTERMEDIATES OF OXIDATIVE PHOSPHORYLATION.

1. Influence of surface potentials on the mitochondrial H+ pump and on lipid-phase transitions.

2. Effects of buformin on the metabolsim of the isolated haemoglobin-free perfused hindlimb of normal rats.

3. Effects of guanidine derivatives on mitochondrial function. IV. Changes in citric acid cycle intermediates and NADH.

4. Calcium-like action of phenethylbiguanide and related compounds: inhibition of pyruvate kinase.

5. Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage.

6. Phenethylbiguanide and the inhibition of hepatic gluconeogenesis in the guinea pig.

7. Effects of guanidine derivatives on mitochondrial function. I. Phenethylbiguanide inhibition of respiration in mitochondria from guinea pig and rat tissues.

Review 8. A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate.