Literature DB >> 566976

Effect of baclofen and dantrolene on bladder stimulator-induced detrusor-sphincter dyssynergia in dogs.

C T Teague, D C Merrill.   

Abstract

The effect of baclofen (Lioresal) and dantrolene (Dantrium) on bladder stimulation-induced detrusor-sphincter dyssynergia was studied in normal and chronic T-10 paraplegic dogs. Dantrolene, which depresses skeletal muscle contractility, had little effect on electrically evoked contractions of the urethral sphincter in dogs. Baclofen, which acts centrally by potentiating presynaptic inhibition, depressed the pudendal to pudendal nerve reflex and decreased urethral resistance during bladder stimulation.

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Year:  1978        PMID： 566976     DOI： 10.1016/0090-4295(78)90179-6

Source DB:  PubMed          Journal:  Urology        ISSN： 0090-4295            Impact factor:   2.649


  6 in total

Review 1.  Neural control of the female urethral and anal rhabdosphincters and pelvic floor muscles.

Authors:  Karl B Thor; William C de Groat
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-05-19       Impact factor: 3.619

2.  Pharmacology of the lower urinary tract.

Authors:  H P Drutz
Journal:  Can Fam Physician       Date:  1987-11       Impact factor: 3.275

Review 3.  Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.

Authors:  A Ward; M O Chaffman; E M Sorkin
Journal:  Drugs       Date:  1986-08       Impact factor: 9.546

4.  Involvement of central GABA receptors in the regulation of the urinary bladder function of anaesthetized rats.

Authors:  U Sillén; B Persson; A Rubenson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1980-11       Impact factor: 3.000

5.  Central effects of baclofen on the L-dopa induced hyperactive urinary bladder of the rat.

Authors:  U Sillén; B Persson; A Rubenson
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-09       Impact factor: 3.000

6.  Management of severe baclofen toxicosis using hemodialysis in conjunction with mechanical ventilation in a cat with chronic kidney disease.

Authors:  Levi Hoffman; Leonel A Londoño; Jenifer Martinez
Journal:  JFMS Open Rep       Date:  2021-07-22
  6 in total

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