Literature DB >> 566678

Reversible inhibition of C1Q release from guinea pig macrophages by 2,2'-dipyridyl: Evidence for a posttranslational hydroxylation step in the biosynthesis of C1Q, a subcomponent of the first component of complement (C1).

W Müller, H Hanauske-Abel, M Loos.   

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Year:  1978        PMID： 566678     DOI： 10.1016/0014-5793(78)80372-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


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  6 in total

1.  Pyridinedicarboxylates, the first mechanism-derived inhibitors for prolyl 4-hydroxylase, selectively suppress cellular hydroxyprolyl biosynthesis. Decrease in interstitial collagen and Clq secretion in cell culture.

Authors:  G Tschank; M Raghunath; V Günzler; H M Hanauske-Abel
Journal:  Biochem J       Date:  1987-12-15       Impact factor: 3.857

2.  The relationship between collagen and C1q biosynthesis in cultured human fibroblasts.

Authors:  K A Fleming; J O McGee
Journal:  Biochem J       Date:  1982-08-15       Impact factor: 3.857

3.  Studies on enzymes of collagen biosynthesis and the synthesis of hydroxyproline in macrophages and mast cells.

Authors:  R Myllylä; H Seppä
Journal:  Biochem J       Date:  1979-08-15       Impact factor: 3.857

4.  Modulation of mRNA expression and secretion of C1q in mouse macrophages by anti-inflammatory drugs and cAMP: evidence for the partial involvement of a pathway that includes cyclooxygenase, prostaglandin E2 and adenylate cyclase.

Authors:  P K Trinder; D Faust; F Petry; M Loos
Journal:  Immunology       Date:  1995-04       Impact factor: 7.397

5.  Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.

Authors:  Serafim Kiriakidis; Simon S Hoer; Natalie Burrows; Gloria Biddlecome; Moddasar N Khan; Cyrille C Thinnes; Christopher J Schofield; Norma Rogers; Marina Botto; Ewa Paleolog; Patrick H Maxwell
Journal:  Kidney Int       Date:  2017-05-12       Impact factor: 10.612

6.  Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is a biomarker of poor prognosis in primary melanomas, and its depletion inhibits melanoma cell invasion and disrupts tumor blood vessel walls.

Authors:  Johanna Eriksson; Vadim Le Joncour; Tiina Jahkola; Susanna Juteau; Pirjo Laakkonen; Olli Saksela; Erkki Hölttä
Journal:  Mol Oncol       Date:  2020-02-28       Impact factor: 6.603
  6 in total

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