Literature DB >> 566469

Neuroleptic-induced "anhedonia" in rats: pimozide blocks reward quality of food.

R A Wise, J Spindler, H deWit, G J Gerberg.   

Abstract

The dopamine receptor blocker pimozide attenuated lever-pressing and running for food reward in hungry rats. In each case the characteristic behavior of pimozide-treated rats was the same as that of undrugged rats when reward was simply withheld. Drug-induced performance difficulties were ruled out by the presence of periods of normal responding in drug-treated animals. Pimozide appears to selectively blunt the rewarding impact of food and other hedonic stimuli.

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Year:  1978        PMID： 566469     DOI： 10.1126/science.566469

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  142 in total

1.  Blockade of D1 dopamine receptors in the ventral tegmental area decreases cocaine reward: possible role for dendritically released dopamine.

Authors:  R Ranaldi; R A Wise
Journal:  J Neurosci       Date:  2001-08-01       Impact factor: 6.167

2.  Effects of dopamine receptor blockade on alimentary behaviors: home cage food consumption, magazine training, operant acquisition, and performance.

Authors:  T N Tombaugh; J Tombaugh; H Anisman
Journal:  Psychopharmacology (Berl)       Date:  1979       Impact factor: 4.530

Review 3.  Reconsidering anhedonia in depression: lessons from translational neuroscience.

Authors:  Michael T Treadway; David H Zald
Journal:  Neurosci Biobehav Rev       Date:  2010-07-11       Impact factor: 8.989

Review 4.  The behavioral pharmacology of effort-related choice behavior: dopamine, adenosine and beyond.

Authors:  John D Salamone; Merce Correa; Eric J Nunes; Patrick A Randall; Marta Pardo
Journal:  J Exp Anal Behav       Date:  2012-01       Impact factor: 2.468

5.  Modeling operant behavior in the Parkinsonian rat.

Authors:  Irene Avila; Mark P Reilly; Federico Sanabria; Diana Posadas-Sánchez; Claudia L Chavez; Nikhil Banerjee; Peter Killeen; Eddie Castañeda
Journal:  Behav Brain Res       Date:  2008-11-27       Impact factor: 3.332

Review 6.  Dopamine and reward: the anhedonia hypothesis 30 years on.

Authors:  Roy A Wise
Journal:  Neurotox Res       Date:  2008-10       Impact factor: 3.911

7.  Affective status in relation to impulsive, motor and motivational symptoms: personality, development and physical exercise.

Authors:  Tomas Palomo; Richard J Beninger; Richard M Kostrzewa; Trevor Archer
Journal:  Neurotox Res       Date:  2008-10       Impact factor: 3.911

8.  Pharmacological characterization of performance on a concurrent lever pressing/feeding choice procedure: effects of dopamine antagonist, cholinomimetic, sedative and stimulant drugs.

Authors:  M S Cousins; W Wei; J D Salamone
Journal:  Psychopharmacology (Berl)       Date:  1994-12       Impact factor: 4.530

9.  Rewarding and psychomotor stimulant effects of endomorphin-1: anteroposterior differences within the ventral tegmental area and lack of effect in nucleus accumbens.

Authors:  Abraham Zangen; Satoshi Ikemoto; James E Zadina; Roy A Wise
Journal:  J Neurosci       Date:  2002-08-15       Impact factor: 6.167

Review 10.  Dopaminergic system in birdsong learning and maintenance.

Authors:  Lubica Kubikova; Lubor Kostál
Journal:  J Chem Neuroanat       Date:  2009-11-10       Impact factor: 3.052
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