Literature DB >> 5663302

Beta thalassemia trait: detection at birth.

Y W Kan, D G Nathan.   

Abstract

The synthesis of alpha, beta, and gamma chains in samples of cord blood was measured by the incorporation of leucine labeled with carbon-14 into these chains. In a newborn affected with beta thalassemia trait, the presence of one beta thalassemia gene was revealed on the 1st day of life by the lower specific radioactivity of the beta chain.

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Year:  1968        PMID： 5663302     DOI： 10.1126/science.161.3841.589

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  3 in total

1.  Expression of the beta-thalassemia gene in the first trimester fetus.

Authors:  H Chang; C B Modell; B P Alter; M J Dickinson; F D Frigoletto; E R Huehns; D G Nathan
Journal:  Proc Natl Acad Sci U S A       Date:  1975-09       Impact factor: 11.205

2.  2006 Association of American Physicians George M. Kober Medal. Introduction of David G. Nathan, MD.

Authors:  Edward J Benz
Journal:  J Clin Invest       Date:  2007-04       Impact factor: 14.808

Review 3.  The prevention of thalassemia.

Authors:  Antonio Cao; Yuet Wai Kan
Journal:  Cold Spring Harb Perspect Med       Date:  2013-02-01       Impact factor: 6.915
  3 in total

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