Literature DB >> 5659369

Turbidimetric assays: the antibiotic dose-response line.

F Kavanagh.   

Abstract

Several antibiotics reduced growth of bacteria without killing them when present in the range of concentrations of significance in assaying. The reduction in growth rate was linearly related to concentration of antibiotic. From this fact may be derived an equation of the form log N = A - BC where N is the concentration of bacteria at the end of the incubation period, C is the concentration of antibiotic, and A and B are constants. This equation is used to guide the selection of the best range of concentrations of unknown for assay and to show the large influence of variations of temperature upon an assay.

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Year:  1968        PMID： 5659369      PMCID： PMC547516          DOI： 10.1128/am.16.5.777-780.1968

Source DB:  PubMed          Journal:  Appl Microbiol        ISSN： 0003-6919


  6 in total

1.  KINETICS AND MECHANISMS OF ACTION OF ANTIBIOTICS ON MICROORGANISMS. I. REPRODUCIBILITY OF ESCHERICHIA COLI GROWTH CURVES AND DEPENDENCE UPON TETRACYCLINE CONCENTRATION.

Authors:  M R BROWN; E R GARRETT
Journal:  J Pharm Sci       Date:  1964-02       Impact factor: 3.534

2.  KINETICS AND MECHANISMS OF ACTION OF ANTIBIOTICS ON MICROORGANISMS. 3. INHIBITORY ACTION OF TETRACYCLINE AND CHLORAMPHENICOL ON ESCHERICHIA COLI ESTABLISHED BY TOTAL AND VIABLE COUNTS.

Authors:  E R GARRETT; G H MILLER
Journal:  J Pharm Sci       Date:  1965-03       Impact factor: 3.534

3.  The linear representation of dosage-response curves in microbial-antibiotic assays.

Authors:  H P TREFFERS
Journal:  J Bacteriol       Date:  1956-07       Impact factor: 3.490

4.  Mode of action of chloramphenicol. IV. Failure of selected natural metabolites to reverse antibiotic action.

Authors:  F E HAHN; R HO; H E HOPPS; J E SMADEL; C L WISSEMAN
Journal:  J Bacteriol       Date:  1956-10       Impact factor: 3.490

5.  Kinetics and mechanisms of action of antibiotics on microorganisms. V. Chloramphenicol and tetracycline affected Escherichia coli generation rates.

Authors:  E R Garrett; G H Miller; M R Brown
Journal:  J Pharm Sci       Date:  1966-06       Impact factor: 3.534

6.  [Toward the standardization of biological assays. Use of a synthetic medium and its application to the determination of tetracycline hydrochloride].

Authors:  D Yavordios; M Carraz; M Manchet; J Koeberle
Journal:  Ann Pharm Fr       Date:  1967 Jul-Aug
  6 in total
  1 in total

1.  Light-scattering methods for antibiotic sensitivity tests.

Authors:  J Murray; P Evans; D W Hukins
Journal:  J Clin Pathol       Date:  1980-10       Impact factor: 3.411
  1 in total

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