Literature DB >> 5657333

4-Leucine-oxytocin: natriuretic, diuretic, and antivasopressin polypeptide.

W Y Chan, V J Hruby, G Flouret, V Du Vigneuad.   

Abstract

During water diuresis in anesthetized rats, 4-leucine-oxytocin increased the urine output and the rates of sodium and chloride excretion. The potassium excretion rate was only slightly increased. During vasopressin-suppressed water diuresis, 4-leucine-oxytocin produced similar effects on urine and electrolyte excretions. In addition, it inhibited the vasopressin-induced free-water reabsorption, and it could reverse reabsorption to freewater clearance.

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Year:  1968        PMID： 5657333     DOI： 10.1126/science.161.3838.280

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  6 in total

1.  300-MHz nuclear magnetic resonance study of oxytocin aqueous solution: conformational implications.

Authors:  A I Brewster; V J Hruby
Journal:  Proc Natl Acad Sci U S A       Date:  1973-12       Impact factor: 11.205

2.  Synthesis of (4-leucine)-arginine-vasotocin, a natriuretic analogue of arginine-vasotocin.

Authors:  D Gillessen; R O Studer; J Rudinger
Journal:  Experientia       Date:  1973-02-15

3.  The natriuretic action of (4-leucine)-arginine-vasotocin.

Authors:  J H Cort; K M Strub; G Häusler; J Rudinger
Journal:  Experientia       Date:  1973-02-15

4.  Competitive inhibitors of neurohypophyseal hormones on adenylate cyclase from the toad urinary bladder.

Authors:  R Walter; M A Kirchberger; V J Hruby
Journal:  Experientia       Date:  1972-08-15

5.  [The syndrome of inappropriate secretion of vasopressin (SIADH) (author's transl)].

Authors:  E Uhlich
Journal:  Klin Wochenschr       Date:  1977-04-01

6.  Threshold and receptor reserve in the action of neurohypophyseal peptides. A study of synergists and antagonists of the hydroosmotic response of the toad urinary bladder.

Authors:  P Eggena; I L Schwartz; R Walter
Journal:  J Gen Physiol       Date:  1970-08       Impact factor: 4.086
  6 in total

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