Literature DB >> 565534

Diazepam inhibits myoblast fusion and expression of muscle specific protein synthesis.

E Bandman, C R Walker, R C Strohman.   

Abstract

The presence of diazepam in culutres of chicken embryo myoblasts arrests normal muscle cell differentiation. High concentrations of the drug reversibly prevent myoblasts from fusing to form multinucleated myotubes. Lower concentrations of diazepam allow cell fusion to occur, but inhibit the synthesis and accumulation of myosin heavy chain, implying that cell fusion does not obligate myoblasts to synthesize and accumulate large quantities of muscle specific protein. The effect of diazepam on muscle cells in culture is direct and specific.

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Year:  1978        PMID： 565534     DOI： 10.1126/science.565534

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

1.  Expression of major histocompatibility complex class I antigens in rat muscle cultures: the possible developmental role in myogenesis.

Authors:  H Honda; A Rostami
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

2.  Early goal directed mobility in the ICU: 'something in the way you move'.

Authors:  Claudia C Dos Santos; Margaret Herridge; Jane Batt
Journal:  J Thorac Dis       Date:  2016-08       Impact factor: 2.895

3.  Tumor selective G2/M cell cycle arrest and apoptosis of epithelial and hematological malignancies by BBL22, a benzazepine.

Authors:  W Xia; S Spector; L Hardy; S Zhao; A Saluk; L Alemane; N L Spector
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

Review 4.  Adverse effects of drugs on muscle.

Authors:  F L Mastaglia
Journal:  Drugs       Date:  1982-10       Impact factor: 9.546

5.  Metalloendoprotease inhibitors that block fusion also prevent biochemical differentiation in L6 myoblasts.

Authors:  E Baldwin; C Kayalar
Journal:  Proc Natl Acad Sci U S A       Date:  1986-11       Impact factor: 11.205

6.  Differentiation of Friend erythroleukemia cells induced by benzodiazepines.

Authors:  J K Wang; J I Morgan; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

7.  Peripheral-type benzodiazepines influence ornithine decarboxylase levels and neurite outgrowth in PC12 cells.

Authors:  J I Morgan; M D Johnson; J K Wang; K H Sonnenfeld; S Spector
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

8.  Trifluoperazine, a calmodulin antagonist, inhibits muscle cell fusion.

Authors:  D Bar-Sagi; J Prives
Journal:  J Cell Biol       Date:  1983-11       Impact factor: 10.539
  8 in total

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