Literature DB >> 565510

DNA replication in Physarum polycephalum: bidirectional replication of DNA within replicons.

S Funderud, R Andreassen, F Haugli.   

Abstract

The direction of replication of DNA within replicons of Physarum polycephalum was studied by pulse-labelling with 5-bromouracil-deoxyriboside (BrdUrd) and 3H-adenosine deoxyriboside (dAdo), followed by ultraviolet- (UV) -photolysis and analysis of molecular weights of single strand DNA fragments on alkaline sucrose gradients. Newly made DNA within replicons at all stages of completion is split in two equal halves upon UV irradiation when BrdUrd was given at the time of initiation of DNA synthesis. This shows that replication within replicons of Physarum polycephalum starts at an origin located in the center of each unit, proceeding bidirectionally from this origin.

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Year:  1978        PMID： 565510      PMCID： PMC342018          DOI： 10.1093/nar/5.3.713

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  SEDIMENTATION STUDIES OF THE SIZE AND SHAPE OF DNA.

Authors:  F W STUDIER
Journal:  J Mol Biol       Date:  1965-02       Impact factor: 5.469

2.  Deoxyribonucleic acid chain growth and organization of replicating units in HeLa cells.

Authors:  S R Planck; G C Mueller
Journal:  Biochemistry       Date:  1977-05-03       Impact factor: 3.162

3.  Cleavage of replicating forms of mitochondrial DNA by EcoRI endonuclease.

Authors:  D L Robberson; D A Clayton; J F Morrow
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

4.  Time sequence of DNA replication in Physarum.

Authors:  R Braun; H Wili
Journal:  Biochim Biophys Acta       Date:  1969-01-21

5.  Bi-directional initiation of DNA synthesis in developing chick erythroblasts.

Authors:  H Weintraub
Journal:  Nat New Biol       Date:  1972-04-19

6.  Studies on the mechanism of DNA replication in Physarum polycephalum.

Authors:  E N Brewer; T E Evans; H H Evans
Journal:  J Mol Biol       Date:  1974-12-05       Impact factor: 5.469

7.  DNA replication in Physarum polycephalum.

Authors:  E N Brewer
Journal:  J Mol Biol       Date:  1972-07-28       Impact factor: 5.469

8.  Isolation and DNA content of nuclei of Physarum polycephalum.

Authors:  J Mohberg; H P Rusch
Journal:  Exp Cell Res       Date:  1971-06       Impact factor: 3.905

9.  Restriction endonuclease cleavage maps of animal mitochondrial DNAs.

Authors:  W M Brown; J Vinograd
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

10.  DNA replication in Physarum polycephalum: characterization of DNA replication products made in vivo in the presence of cycloheximide in strains sensitive and resistant to cycloheximide.

Authors:  S Funderud; F Haugli
Journal:  Nucleic Acids Res       Date:  1977-02       Impact factor: 16.971
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  6 in total

1.  Replication initiation and elongation fork rates within a differentially expressed human multicopy locus in early S phase.

Authors:  R S Scott; K Y Truong; J M Vos
Journal:  Nucleic Acids Res       Date:  1997-11-15       Impact factor: 16.971

2.  Mapping of a replication origin within the promoter region of two unlinked, abundantly transcribed actin genes of Physarum polycephalum.

Authors:  M Bénard; C Lagnel; D Pallotta; G Pierron
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

3.  DNA replication in Physarum polycephalum: UV photolysis of maturing 5-bromo-deoxyuridine substituted DNA.

Authors:  S Funderud; R Andreassen; F Haugli
Journal:  Nucleic Acids Res       Date:  1978-09       Impact factor: 16.971

4.  Isolation of newly replicated chromatin by using shallow metrizamide gradients.

Authors:  R F Murphy; R B Wallace; J Bonner
Journal:  Proc Natl Acad Sci U S A       Date:  1980-06       Impact factor: 11.205

5.  DNA replication in Physarum polycephalum: electron microscopic and autoradiographic analysis of replicating DNA from defined stages of the S-period.

Authors:  S Funderud; R Andreassen; F Haugli
Journal:  Nucleic Acids Res       Date:  1979-04       Impact factor: 16.971

6.  Two alleles of a developmentally regulated alpha-tubulin locus in Physarum polycephalum replicate on different schedules.

Authors:  D B Cunningham; W F Dove
Journal:  Mol Cell Biol       Date:  1993-01       Impact factor: 4.272
  6 in total

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