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Literature DB >> 564999

Effect of chronic ethanol administration on cholesterol and bile acid synthesis in vivo.

Abstract

Chronic administration of ethanol failed to a stimulate the hepatic rate of cholesterol synthesis in meal-fed rats. In contrast, chronic ethanol feeding caused a 50% inhibition in the rate of incorporation of [4-14C] cholesterol to bile acids in the bile-duct cannulated rats. It is, therefore, suggested that the decreased rate of cholesterol degradation to bile acids may play an important role in ethanol-induced accumulation of cholesterol in liver.

Entities: Chemical Species

Mesh：

Substances：

Year: 1978 PMID： 564999 DOI： 10.1007/bf02533255

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

12 in total

1. IDENTIFICATION OF ALLODEOXYCHOLIC ACID AS THE MAJOR COMPONENT OF GALLSTONES INDUCED IN THE RABBIT BY 5-ALPHA-CHOLESTAN-3-BETA-OL.

Authors: A F HOFMANN; E H MOSBACH
Journal: J Biol Chem Date: 1964-09 Impact factor: 5.157

2. C14-Cholesterol. III. Excretion of carbons 4 and 26 in feces, urine, and bile.

Authors: M D SIPERSTEIN; I L CHAIKOFF
Journal: J Biol Chem Date: 1952-09 Impact factor: 5.157

3. Measurement of rate of rat liver sterol synthesis in vivo using tritiated water.

Authors: M R Lakshmanan; R L Veech
Journal: J Biol Chem Date: 1977-07-10 Impact factor: 5.157

4. Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities.

Authors: M R Lakshmanan; R L Veech
Journal: J Lipid Res Date: 1977-05 Impact factor: 5.922

5. Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis.

Authors: J M Dietschy; M S Brown
Journal: J Lipid Res Date: 1974-09 Impact factor: 5.922

6. Cholesterol-7 alpha-hydroxylase of pigeon liver microsomes.

Authors: F H Hulcher; W H Oleson; H B Lofland
Journal: Arch Biochem Biophys Date: 1974-11 Impact factor: 4.013

7. Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.

Authors: H Danielsson; K Einarsson; G Johansson
Journal: Eur J Biochem Date: 1967-07

8. Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro.

Authors: J Van Cantfort; J Gielen
Journal: Eur J Biochem Date: 1975-06-16

Effect of chronic ethanol administration on cholesterol and bile acid synthesis in vivo.

1. IDENTIFICATION OF ALLODEOXYCHOLIC ACID AS THE MAJOR COMPONENT OF GALLSTONES INDUCED IN THE RABBIT BY 5-ALPHA-CHOLESTAN-3-BETA-OL.

2. C14-Cholesterol. III. Excretion of carbons 4 and 26 in feces, urine, and bile.

3. Measurement of rate of rat liver sterol synthesis in vivo using tritiated water.

4. Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7alpha-hydroxylase activities.

5. Effect of alterations of the specific activity of the intracellular acetyl CoA pool on apparent rates of hepatic cholesterogenesis.

6. Cholesterol-7 alpha-hydroxylase of pigeon liver microsomes.

7. Effect of biliary drainage on individual reactions in the conversion of cholesterol to taurochlic acid. Bile acids and steroids 180.

8. Cholesterol 7alpha-hydroxylase. 2. Biochemical properties and participation of endogenous cholesterol in the assay in vitro.

9. Effect of ethanol on cholesterol and bile acid metabolism.

10. Bile acid synthesis in the isolated, perfused rabbit liver.

1. Secretion of high density lipoprotein by the isolated perfused alcoholic rat liver.

Review 2. Molecular mechanisms of alcoholic fatty liver.