Literature DB >> 564640

Procaine, lidocaine, and ketamine inhibit histamine-induced contracture of guinea pig tracheal muscle in vitro.

H T Wanna, S D Gergis.   

Abstract

In vitro experiments using guinea pig tracheal smooth muscle were performed to compare the relaxant properties of procaine, lidocaine, and ketamine following contracture induced by histamine. Procaine produced a spasmolytic effect in a dose-related manner. In the doses tested, relaxation induced by procaine was more pronounced than that produced by either lidocaine or ketamine, although the latter 2 drugs also had a significant spasmolytic effect.

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Year:  1978        PMID: 564640     DOI: 10.1213/00000539-197801000-00005

Source DB:  PubMed          Journal:  Anesth Analg        ISSN: 0003-2999            Impact factor:   5.108


  4 in total

Review 1.  Perioperative management of the asthmatic patient.

Authors:  C A Hirshman
Journal:  Can J Anaesth       Date:  1991-05       Impact factor: 5.063

2.  General anesthetics: a comparative review of pharmacodynamics.

Authors:  S B Milam
Journal:  Anesth Prog       Date:  1984 May-Jun

3.  Ketamine and its isomers have equipotent relaxant effects on tracheal smooth muscle contracted by tachykinins.

Authors:  K Hirota; T Sato; S F Rabito; E K Zsigmond; A Matsuki
Journal:  J Anesth       Date:  1996-03       Impact factor: 2.078

4.  Effects of ketamine and halothane on normal and asthmatic smooth muscle of the airway in guinea pigs.

Authors:  A Cabanas; J F Souhrada; J A Aldrete
Journal:  Can Anaesth Soc J       Date:  1980-01
  4 in total

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