Literature DB >> 5644261

Enzyme-catalyzed reactions of the carcinogen N-hydroxy-2-fluorenylacetamide with nucleic acid.

C M King, B Phillips.   

Abstract

A protein fraction obtained by gel filtration of a 105,000g supernatant of rat liver catalyzes three reactions of the hepatocarcinogen N-hydroxy-2-fluorenylacetamide with nucleic acid. Cofactor requirements and isotopic studies suggest that the reactive intermediates involved may be N-2-fluorenylhydroxylamine, and phosphate and sulfate esters of N-hydroxy-2-fluorenylacetamide.

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Year:  1968        PMID： 5644261     DOI： 10.1126/science.159.3821.1351

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  12 in total

1.  Induction of cytokinin-independent tobacco tissues by substituted fluorenes.

Authors:  T W Bednar; E M Linsmaier-Bednar
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

Review 2.  [The activation of carcinogenic aromatic amines in metabolism].

Authors:  H G Neumann
Journal:  Klin Wochenschr       Date:  1970-08-15

3.  Relationship between the genetically determined acetylator phenotype and DNA damage induced by hydralazine and 2-aminofluorene in cultured rabbit hepatocytes.

Authors:  C A McQueen; C J Maslansky; I B Glowinski; S B Crescenzi; W W Weber; G M Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

4.  Reactive phosphate ester of the carcinogen 2-(N-hydroxy)acetamido-fluorene.

Authors:  P D Lotlikar; M B Wasserman
Journal:  Biochem J       Date:  1970-12       Impact factor: 3.857

5.  Aminofluorene-DNA adduct formation in Salmonella typhimurium exposed to the carcinogen N-hydroxy-2-acetylaminofluorene.

Authors:  D T Beranek; G L White; R H Heflich; F A Beland
Journal:  Proc Natl Acad Sci U S A       Date:  1982-09       Impact factor: 11.205

6.  Some historical aspects of N-aryl carcinogens and their metabolic activation.

Authors:  J A Miller; E C Miller
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031

Review 7.  The role of glutathione in detoxication.

Authors:  B Ketterer; B Coles; D J Meyer
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031

8.  Characterization and expression of hepatic sulfotransferase involved in the metabolism of N-substituted aryl compounds.

Authors:  Y Yamazoe; S Ozawa; K Nagata; D W Gong; R Kato
Journal:  Environ Health Perspect       Date:  1994-10       Impact factor: 9.031

Review 9.  Computer-assisted mechanistic structure-activity studies: application to diverse classes of chemical carcinogens.

Authors:  G H Loew; M Poulsen; E Kirkjian; J Ferrell; B S Sudhindra; M Rebagliati
Journal:  Environ Health Perspect       Date:  1985-09       Impact factor: 9.031

Review 10.  Sulfation and glucuronidation as competing pathways in the metabolism of hydroxamic acids: the role of N,O-sulfonation in chemical carcinogenesis of aromatic amines.

Authors:  G J Mulder; J H Meerman
Journal:  Environ Health Perspect       Date:  1983-03       Impact factor: 9.031
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