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Literature DB >> 5643063

Drug resistance of staphylococci. VI. Genetic determinant for chloramphenicol resistance.

Abstract

Naturally occurring strains of staphylococci which are resistant to chloramphenicol (CM) inactivate this antibiotic. One of the inactivation products of CM showed the chromatographic behavior of 3-acetoxychloramphenicol. Induction of resistance occurred after prior exposure to subinhibitory concentrations of the antibiotic. The resistance of induced populations, as well as CM-inactivation ability, was decreased when they were grown in CM-free medium. The CM-inactivation property was transduced together with CM resistance. Transductional analysis and CM-resistance elimination experiments indicated that CM resistance in naturally occurring strains of staphylococci is mainly accounted for by inactivation of the drug.

Entities: Chemical

Mesh：

Substances：
Acridines
Chloramphenicol

Year: 1968 PMID： 5643063 PMCID： PMC252106 DOI： 10.1128/jb.95.3.886-892.1968

Source DB: PubMed Journal: J Bacteriol ISSN： 0021-9193 Impact factor: 3.490

15 in total

1. ELIMINATION OF PENICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS BY TREATMENT WITH ACRIFLAVINE.

Authors: H HASHIMOTO; K KONO; S MITSUHASHI
Journal: J Bacteriol Date: 1964-07 Impact factor: 3.490

2. ANALYSIS BY TRANSDUCTION OF MUTATIONS AFFECTING PENICILLINASE FORMATION IN STAPHYLOCOCCUS AUREUS.

Authors: R P NOVICK
Journal: J Gen Microbiol Date: 1963-10

3. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.

Authors: S Okamoto; Y Suzuki
Journal: Nature Date: 1965-12-25 Impact factor: 49.962

6. Kinetics of induction and purification of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus.

Authors: E Winshell; W V Shaw
Journal: J Bacteriol Date: 1969-06 Impact factor: 3.490

6 in total

Drug resistance of staphylococci. VI. Genetic determinant for chloramphenicol resistance.

1. ELIMINATION OF PENICILLIN RESISTANCE OF STAPHYLOCOCCUS AUREUS BY TREATMENT WITH ACRIFLAVINE.

2. ANALYSIS BY TRANSDUCTION OF MUTATIONS AFFECTING PENICILLINASE FORMATION IN STAPHYLOCOCCUS AUREUS.

3. Chloramphenicol-, dihydrostreptomycin-, and kanamycin-inactivating enzymes from multiple drug-resistant Escherichia coli carrying episome 'R'.

4. Transferable R factors in enteric bacteria causing infection of the genitourinary tract.

Review 5. Epidemiological and genetical study of drug resistance in Staphylococcus aureus.

6. Drug resistance to staphylococci. 3. Resistance to some macrolide antibiotics and inducible system.

7. The enzymatic acetylation of chloramphenicol by extracts of R factor-resistant Escherichia coli.

8. Basis of chloramphenicol resistance in naturally isolated resistant staphylococci.

9. Transmissible drug-ressistance factor R with special reference to replication.

10. Drug resistance of enteric bacteria. IX. Distribution of R factors in gram-negative bacteria from clinical sources.

1. Inducible high resistance to colistin in Proteus strains.

2. New type of R factors incapable of inactivating chloramphenicol.

3. Isolation of the rec mutants in Staphylococcus aureus.

4. R plasmids in Corynebacterium xerosis strains.

5. Mechanism of Chloramphenicol Resistance in Staphylococcus epidermidis.

6. Kinetics of induction and purification of chloramphenicol acetyltransferase from chloramphenicol-resistant Staphylococcus aureus.