Literature DB >> 563466

Predisposition to spina bifida: Search for a relation to maternal gastric acid secretion.

P A Stanway, I M Samloff, C J Brace, J H Renwick.   

Abstract

The peak acid output of the stomach in a group of 71 mothers of spina bifida children and in 71 matched controls was estimated indirectly by the serum level of group I pepsinogens. The mean levels did not differ significantly, suggesting that the conjectured teratogen is not specially acid-labile. The variance was significantly higher in index subjects than in controls, but the interpretation of this finding is not clear.

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Year:  1977        PMID: 563466      PMCID: PMC1013615          DOI: 10.1136/jmg.14.5.332

Source DB:  PubMed          Journal:  J Med Genet        ISSN: 0022-2593            Impact factor:   6.318


  10 in total

1.  Serum group I pepsinogens by radioimmunoassay in control subjects and patients with peptic ulcer.

Authors:  I M Samloff; W M Liebman; N M Panitch
Journal:  Gastroenterology       Date:  1975-07       Impact factor: 22.682

2.  Present status and possibilities on ion exchange compounds as tubeless agents for determining gastric acidity.

Authors:  H L SEGAL; L L MILLER
Journal:  Gastroenterology       Date:  1955-10       Impact factor: 22.682

3.  Teratogenicity of the solanum alkaloid solasodine and of 'Kennebec' potato sprouts in hamsters.

Authors:  R F Keeler; D Brown; D R Douglas; G F Stallknecht; S Young
Journal:  Bull Environ Contam Toxicol       Date:  1976-05       Impact factor: 2.151

4.  A study of the relationship between serum group I pepsinogen levels and gastric acid secretion.

Authors:  I M Samloff; D M Secrist; E Passaro
Journal:  Gastroenterology       Date:  1975-12       Impact factor: 22.682

5.  Neural tube defects in a country town. Conformation of clustering within a particularly small area.

Authors:  M J Aylett; C J Roberts; S Lloyd
Journal:  Br J Prev Soc Med       Date:  1974-08

6.  Radioimmunoassay of group I pepsinogens in serum.

Authors:  I M Samloff; W M Liebman
Journal:  Gastroenterology       Date:  1974-04       Impact factor: 22.682

7.  Comparison of the teratogenicity in rats of certain potato-type alkaloids and the veratrum teratogen cyclopamine.

Authors:  R F Keeler
Journal:  Lancet       Date:  1973-05-26       Impact factor: 79.321

8.  Gastric cancer--increased frequency in patients with achlorhydria.

Authors:  H L Segal; I M Samloff
Journal:  Am J Dig Dis       Date:  1973-04

9.  Teratogenic compounds of Veratrum californicum (Durand). XI. Gestational chronology and compound specificity in rabbits.

Authors:  R F Keeler
Journal:  Proc Soc Exp Biol Med       Date:  1971-04

10.  Spina bifida, exencephaly, and cranial bleb produced in hamsters by the solanum alkaloid solasodine.

Authors:  R F Keeler; S Young; D Brown
Journal:  Res Commun Chem Pathol Pharmacol       Date:  1976-04
  10 in total
  1 in total

1.  Predisposition to spina bifida.

Authors:  P A Stanway; I M Samloff; C J Brace; J H Renwick; C J Schorah
Journal:  J Med Genet       Date:  1978-12       Impact factor: 6.318

  1 in total

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