Literature DB >> 563082

Behavioral effects of neuroleptics, apomorphine and amphetamine after bilateral lesion of the locus coeruleus in rats.

W Kostowski, M Jerlicz, A Bidzinski, M Hauptmann.   

Abstract

Bilateral lesions of the locus coeruleus (LC) markedly increased susceptibility to the cateleptogenic effects of neuroleptics. The apomorphine-induced stereotypy was enhanced in rats with lesioned LC whilst amphetamine stereotypy was only slightly increased. No changes in locomotor activity have been observed in LC-lesioned rats treated with apomorphine and amphetamine. This data indicates that lesions of the LC produce decreased activity of dopaminergic brain neurons as well as supersensitivity of dopaminergic receptors.

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Year:  1977        PMID： 563082     DOI： 10.1016/0091-3057(77)90222-2

Source DB:  PubMed          Journal:  Pharmacol Biochem Behav        ISSN： 0091-3057            Impact factor:   3.533


  7 in total

1.  Functional antagonism between dopamine and noradrenaline within the caudate nucleus of cats: a phenomenon of rhythmically changing susceptibility.

Authors:  A R Cools; P A van Dongen; H J Janssen; A A Megens
Journal:  Psychopharmacology (Berl)       Date:  1978-12-08       Impact factor: 4.530

2.  Evidence for existence of two opposite noradrenergic brain systems controlling behavior.

Authors:  W Kostowski; M Jerlicz; A Bidziński; M Hauptmann
Journal:  Psychopharmacology (Berl)       Date:  1978-12-08       Impact factor: 4.530

3.  6-Hydroxydopamine lesion of locus coeruleus and the antiparkinsonian potential of NMDA-receptor antagonists in rats.

Authors:  N Rückert; M Bubser; W J Schmidt
Journal:  J Neural Transm (Vienna)       Date:  1997       Impact factor: 3.575

4.  Low doses of corticotropin-releasing factor potentiate amphetamine-induced stereotyped behavior.

Authors:  B J Cole; G F Koob
Journal:  Psychopharmacology (Berl)       Date:  1989       Impact factor: 4.530

5.  Amphetamine impairs the discriminative performance of rats with dorsal noradrenergic bundle lesions on a 5-choice serial reaction time task: new evidence for central dopaminergic-noradrenergic interactions.

Authors:  B J Cole; T W Robbins
Journal:  Psychopharmacology (Berl)       Date:  1987       Impact factor: 4.530

6.  Potentiation of the effects of reward-related stimuli by dopaminergic-dependent mechanisms in the nucleus accumbens.

Authors:  M Cador; J R Taylor; T W Robbins
Journal:  Psychopharmacology (Berl)       Date:  1991       Impact factor: 4.530

7.  The effect of the alpha2-adrenoreceptor antagonist idazoxan against 6-hydroxydopamine-induced Parkinsonism in rats: multiple facets of action?

Authors:  J Srinivasan; Werner J Schmidt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2004-04-29       Impact factor: 3.000
  7 in total

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