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Literature DB >> 562965

Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii.

Abstract

Bioassay-guided fractionation of the aqueous alcoholic extract of the marine sponge Verongia spengelii for tumor inhibitory agents led to the isolation of aplysinopsin, a new tryptophan derivative recently reported from another sponge Thorecta aplysinopsis. Aplysinopsin showed cytotoxicity against the KB, P388 and L1210 cell cultures.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1977 PMID： 562965

Source DB: PubMed Journal: Lloydia ISSN： 0024-5461

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Cited

11 in total

1. Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.

Authors: David F Cummings; Diana C Canseco; Pratikkumar Sheth; James E Johnson; John A Schetz
Journal: Bioorg Med Chem Date: 2010-05-15 Impact factor: 3.641

2. Fluorous parallel synthesis of a hydantoin/thiohydantoin library.

Authors: Yimin Lu; Wei Zhang
Journal: Mol Divers Date: 2005 Impact factor: 2.943

3. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.

Authors: Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Peter A Crooks
Journal: Bioorg Med Chem Lett Date: 2011-01-11 Impact factor: 2.823

4. Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.

Authors: Y Thirupathi Reddy; P Narsimha Reddy; Srinivas Koduru; Chendil Damodaran; Peter A Crooks
Journal: Bioorg Med Chem Date: 2010-03-27 Impact factor: 3.641

5. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines.

Authors: Narsimha Reddy Penthala; Thirupathi Reddy Yerramreddy; Peter A Crooks
Journal: Bioorg Med Chem Lett Date: 2009-11-22 Impact factor: 2.823

10. Smenamides A and B, chlorinated peptide/polyketide hybrids containing a dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research.

Authors: Roberta Teta; Elena Irollo; Gerardo Della Sala; Giuseppe Pirozzi; Alfonso Mangoni; Valeria Costantino
Journal: Mar Drugs Date: 2013-11-08 Impact factor: 5.118

Aplysinopsin: antineoplastic tryptophan derivative from the marine sponge Verongia spengelii.

1. Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.

2. Fluorous parallel synthesis of a hydantoin/thiohydantoin library.

3. Synthesis and in vitro screening of novel N-benzyl aplysinopsin analogs as potential anticancer agents.

4. Aplysinopsin analogs: Synthesis and anti-proliferative activity of substituted (Z)-5-(N-benzylindol-3-ylmethylene)imidazolidine-2,4-diones.

5. Microwave assisted synthesis and in vitro cytotoxicities of substituted (Z)-2-amino-5-(1-benzyl-1H-indol-3-yl)methylene-1-methyl-1H-imidazol-4(5H)-ones against human tumor cell lines.

Review 6. Aplysinopsins--marine indole alkaloids: chemistry, bioactivity and ecological significance.

7. Secondary metabolites from three Florida sponges with antidepressant activity.

Review 8. The Bucherer-Bergs Multicomponent Synthesis of Hydantoins-Excellence in Simplicity.

9. Anti-Leukemic Properties of Aplysinopsin Derivative EE-84 Alone and Combined to BH3 Mimetic A-1210477.

10. Smenamides A and B, chlorinated peptide/polyketide hybrids containing a dolapyrrolidinone unit from the Caribbean sponge Smenospongia aurea. Evaluation of their role as leads in antitumor drug research.