Literature DB >> 562761

Rotational behavior induced in rats by intranigral application of GABA-related drugs and GABA antagonists.

H R Olpe, H Schellenberg, W P Koella.   

Abstract

GABA and GABA-related drugs such as muscimol, gamma-hydroxybutyric acid and baclofen injected unilaterally into the substantia nigra of rats elicited contraversive turning. Unilateral injections of picrotoxin and bicuculline produced either ipsi- or contraversive turning depending on the volume of vehicle. I.p. applied haloperidol did not abolish the muscimol-induced turning. This and the direction of rotational behavior suggests that the turning behavior elicited by GABA-related drugs is not mediated by the nigrostriatal dopaminergic tract.

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Year:  1977        PMID： 562761     DOI： 10.1016/0014-2999(77)90012-7

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  20 in total

1.  Postural and anticonvulsant effects of inhibition of the rat subthalamic nucleus.

Authors:  D Dybdal; K Gale
Journal:  J Neurosci       Date:  2000-09-01       Impact factor: 6.167

2.  Behavioral differences induced by muscimol selectively injected into pars compacta and pars reticulata of Substantia nigra.

Authors:  J Arnt; J Scheel-Krüger
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-12       Impact factor: 3.000

3.  Rotational behaviour and striatal dopamine metabolism following unilateral activation of nigral GABA mechanisms: GABA-like modulation of dopaminergic and non-dopaminergic neurons in rat substantia nigra [proceedings].

Authors:  J L Waddington
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

4.  The effects of muscimol and picrotoxin injections into the cat substantia nigra.

Authors:  S Wolfarth; W Kolasiewicz; K H Sontag
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1981-08       Impact factor: 3.000

5.  In vivo release of dopamine from rat striatum, substantia nigra and prefrontal cortex: differential modulation by baclofen.

Authors:  M Santiago; A Machado; J Cano
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

Review 6.  Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.

Authors:  A V Christensen; O Svendsen; P Krogsgaard-Larsen
Journal:  Pharm Weekbl Sci       Date:  1982-10-22

7.  Behavioural effects mediated by unilateral nigral dopamine receptor stimulation in the rat.

Authors:  E Kelly; P Jenner; C D Marsden
Journal:  Exp Brain Res       Date:  1984       Impact factor: 1.972

8.  Effect of sodium valproate on motor function regulated by the activation of GABA receptors.

Authors:  A Kuruvilla; N J Uretsky
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

Review 9.  Physiological and behavioral studies with muscimol.

Authors:  F V DeFeudis
Journal:  Neurochem Res       Date:  1980-10       Impact factor: 3.996

10.  Evidence for a GABAergic nigrothalamic pathway in the rat. I. Behavioural and biochemical studies.

Authors:  I C Kilpatrick; M S Starr; A Fletcher; T A James; N K MacLeod
Journal:  Exp Brain Res       Date:  1980       Impact factor: 1.972
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