Literature DB >> 56231

Pulse cytophotometric analysis of cell cycle perturbation with bleomycin in vitro.

B Barlogie, B Drewinko, J Schumann, E J Freireich.   

Abstract

The kinetic response of a human lymphoma cell line to bleomycin has been analyzed, using an ICP-11 pulse cytophotometer. Bleomycin induced a delay of the cell-cycle traverse in G2 phase, the extent and recovery of which depended on drug concentration, exposure time, and cell cycle stage where treatment was applied. Different phase sensitivity for lethal damage (G2 phase) and kinetic response (early S phase) were documented. Recovery from G2 block did not predict for unimpaired reproductive capacity.

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Year:  1976        PMID： 56231

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  9 in total

Review 1.  Managing keloid scars: From radiation therapy to actual and potential drug deliveries.

Authors:  Chenyu Huang; Longwei Liu; Zhifeng You; Yanan Du; Rei Ogawa
Journal:  Int Wound J       Date:  2019-03-12       Impact factor: 3.315

Review 2.  Mechanisms of bleomycin-induced lung damage.

Authors:  J Hay; S Shahzeidi; G Laurent
Journal:  Arch Toxicol       Date:  1991       Impact factor: 5.153

3.  Site-specific cleavage of RNA by Fe(II).bleomycin.

Authors:  B J Carter; E de Vroom; E C Long; G A van der Marel; J H van Boom; S M Hecht
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

4.  Synchronization of human leukemic cells: relevance for high-resolution chromosome banding.

Authors:  J H Gallo; J V Ordonez; G E Brown; J R Testa
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

5.  Flow-cytophotometric studies on urine sediments of patients treated with anti-cancer-drugs.

Authors:  H W Schwabe; H D Adolphs; J Hartlapp
Journal:  Urol Res       Date:  1983

6.  In vitro effects of recombinant human growth hormone on growth of human gastric cancer cell line BGC823 cells.

Authors:  Jia-Yong Chen; Dao-Ming Liang; Ping Gan; Yi Zhang; Jie Lin
Journal:  World J Gastroenterol       Date:  2004-04-15       Impact factor: 5.742

7.  Collagen gel culture of rat mammary tumor cells as an assay system for determination of therapeutic efficacy of chemotherapeutic agents.

Authors:  D K Sinha; C J White
Journal:  In Vitro Cell Dev Biol       Date:  1988-06

8.  The disaccharide moiety of bleomycin facilitates uptake by cancer cells.

Authors:  Benjamin R Schroeder; M Imran Ghare; Chandrabali Bhattacharya; Rakesh Paul; Zhiqiang Yu; Paul A Zaleski; Trevor C Bozeman; Michael J Rishel; Sidney M Hecht
Journal:  J Am Chem Soc       Date:  2014-09-23       Impact factor: 15.419

9.  Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma.

Authors:  Antoinette C van der Kuyl; Remco van den Burg; Fokla Zorgdrager; John T Dekker; Jolanda Maas; Carel J M van Noesel; Jaap Goudsmit; Marion Cornelissen
Journal:  BMC Cancer       Date:  2002-09-02       Impact factor: 4.430
  9 in total

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