Literature DB >> 561703

Induction of rotational behaviour by intranigral baclofen suggests possible GABA-agonist activity.

J L Waddington.   

Abstract

In rats, unilateral injections of the GABA-derivative baclofen into the zona reticulata of the substantia nigra produced a contralateral rotation that was translated to ipsilateral rotation under the influence of amphetamine. These results mimic those following unilateral elevation of GABA levels in the substantia nigra and suggest that baclofen may have some GABA agonist activity following intracerebral injection.

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Year:  1977        PMID： 561703     DOI： 10.1007/bf01920172

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  16 in total

1.  Synaptic mechanisms in the substantia nigra.

Authors:  A Dray; D W Straughan
Journal:  J Pharm Pharmacol       Date:  1976-04       Impact factor: 3.765

2.  Antagonism between Lioresal and substance P in rat spinal cord.

Authors:  K Saito; S Konishi; M Otsuka
Journal:  Brain Res       Date:  1975-10-24       Impact factor: 3.252

3.  Evidence for an inhibitory gabergic control of the meso-limbic dopamine neurons: possibility of improving treatment of schizophrenia by combined treatment with neuroleptics and gabergic drugs.

Authors:  K Fuxe; T Hökfelt; A Ljungdahl; L Agnati; O Johansson; M Perez de la Mora
Journal:  Med Biol       Date:  1975-06

4.  The behavioural effects of EOS-induced changes in substantia nigra GABA levels [proceedings].

Authors:  G Koob; M del Fiacco; S D Iversen
Journal:  Br J Pharmacol       Date:  1976-11       Impact factor: 8.739

5.  Conditioned suppression: dissociation of learning in baclofen treated rats.

Authors:  P Soubrie; P Simon; J J Boissier
Journal:  Experientia       Date:  1976-10-15

6.  Effects of aminooxyacetic acid and baclofen on the catalepsy and on the increase of mesolimbic and striatal dopamine turnover induced by haloperidol in rats.

Authors:  I Kääriäinen
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1976-09

7.  The action of beta-phenyl-GABA derivatives on neurones of the cat cerebral cortex.

Authors:  J Davies; J C Watkins
Journal:  Brain Res       Date:  1974-04-26       Impact factor: 3.252

8.  Evidence for the existence of substance P-containing fibres in striato-nigral and pallido-nigral pathways in rat brain.

Authors:  I Kanazawa; P C Emson; A C Cuello
Journal:  Brain Res       Date:  1977-01-07       Impact factor: 3.252

9.  Is Lioresal (Baclofen) an antagonist of substance P?

Authors:  K J Fotherby; N J Morrish; R W Ryall
Journal:  Brain Res       Date:  1976-08-20       Impact factor: 3.252

10.  Effect of sodium valproate on tardive dyskinesia.

Authors:  M Linnoila; M Viukari; O Kietala
Journal:  Br J Psychiatry       Date:  1976-08       Impact factor: 9.319
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  3 in total

1.  Drug effects in a GABA-dependent rotational behaviour model and on [3H]-GABA receptor binding: studies with the enantiomers of baclofen HCl [proceedings].

Authors:  A J Cross; J L Waddington; T J Crow
Journal:  Br J Pharmacol       Date:  1978-11       Impact factor: 8.739

2.  Rotational behaviour and striatal dopamine metabolism following unilateral activation of nigral GABA mechanisms: GABA-like modulation of dopaminergic and non-dopaminergic neurons in rat substantia nigra [proceedings].

Authors:  J L Waddington
Journal:  Br J Pharmacol       Date:  1978-06       Impact factor: 8.739

3.  Baclofen and muscimol: behavioural and neurochemical sequelae of unilateral intranigral administration and effects on 3H-GABA receptor binding.

Authors:  J L Waddington; A J Cross
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-04       Impact factor: 3.000
  3 in total

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