Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The effects of 4-imidazolyl-3-amino-2-butanone (McN-A-1293), a specific histidine decarboxylase inhibitor, on the expression of morphine tolerance and physical dependence in mice.

Literature DB >> 561519

The effects of 4-imidazolyl-3-amino-2-butanone (McN-A-1293), a specific histidine decarboxylase inhibitor, on the expression of morphine tolerance and physical dependence in mice.

Abstract

McN-A-1293, a specific histidine decarboxylase inhibitor administered intracisternally in the 'withdrawal' phase, significantly suppressed the expression of morphine tolerance. Severity of withdrawal, assessed by percentage body weight loss, was significantly enhanced although incidence of jumping was unaltered. The opposite effects of this compound on morphine tolerance and withdrawal suggest that tolerance and physical dependence are based on different underlying mechanisms.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1977 PMID： 561519 DOI： 10.1007/bf01969979

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

Keyword Cloud
References

10 in total

1. Possible role of brain histamine in morphine addiction.

Authors: R W Henwood; I M Mazurikiewicz-Kwilecki
Journal: Life Sci Date: 1975-07-01 Impact factor: 5.037

2. The effects of L-histidine and of specific histamine receptor agonists, on the expression of morphine tolerance and physical dependence in mice.

Authors: C L Wong; M B Roberts
Journal: Agents Actions Date: 1976-09

3. The effect of thiazol-4-yimethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice.

Authors: K S Hui
Journal: Experientia Date: 1976-10-15

4. Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.

Authors: H O Collier; D L Francis; C Schneider
Journal: Nature Date: 1972-05-26 Impact factor: 49.962

9. The possible role of brain histamine and H1 and H2 receptors in the development of morphine tolerance and physical dependence in mice.

Authors: C L Wong; M B Roberts
Journal: Agents Actions Date: 1975-12

10. 4-imidazolyl-3-amino-2-butanone (McN-A-1293), a new specific inhibitor of histidine decarboxylase.

Authors: R J Taylor; F J Leinweber; G A Braun
Journal: Biochem Pharmacol Date: 1973-09-15 Impact factor: 5.858

10 in total

The effects of 4-imidazolyl-3-amino-2-butanone (McN-A-1293), a specific histidine decarboxylase inhibitor, on the expression of morphine tolerance and physical dependence in mice.

1. Possible role of brain histamine in morphine addiction.

2. The effects of L-histidine and of specific histamine receptor agonists, on the expression of morphine tolerance and physical dependence in mice.

3. The effect of thiazol-4-yimethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice.

4. Modification of morphine withdrawal by drugs interacting with humoral mechanisms: some contradictions and their interpretation.

5. Quantitative aspects of precipitated abstinence in morphine-dependent rats.

6. Improved fluorometric assay of histamine: condensation with O-phthalaldehyde at -20 degrees C.

7. Fluorometric determination of histamine with OPT: optimum reaction conditions and tests of identity.

8. An improved implantation pellet for rapid induction of morphine dependence in mice.

9. The possible role of brain histamine and H1 and H2 receptors in the development of morphine tolerance and physical dependence in mice.

10. 4-imidazolyl-3-amino-2-butanone (McN-A-1293), a new specific inhibitor of histidine decarboxylase.