Literature DB >> 560908

Potentiation of the action of azaserine on the rat pancreas by raw soya bean flour.

R G Morgan, D A Levinson, D Hopwood, J H Saunders, K G Wormsley.   

Abstract

Rats were treated with raw soya flour to produce pancreatic hypertrophy and also received azaserine, a pancreatic carcinogen. The combined treatment resulted in the development of large numbers of hyperplastic nodules in the acinar tissue of the rat pancreas. We conclude that the pancreas of the rat stimulated to proliferate by raw soya flour provides a sensitive model for detecting and studying pancreatic carcinogens.

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Year:  1977        PMID: 560908     DOI: 10.1016/s0304-3835(77)94455-x

Source DB:  PubMed          Journal:  Cancer Lett        ISSN: 0304-3835            Impact factor:   8.679


  8 in total

1.  What do we know about the effects of trypsin inhibitors on the pancreas?

Authors:  P M Pour
Journal:  Int J Pancreatol       Date:  1986-10

2.  Effect of experimental pancreatic growth on the content of xenobiotic-metabolising enzymes in the pancreas.

Authors:  J Ross; J A Barrowman
Journal:  Gut       Date:  1987       Impact factor: 23.059

3.  Epidemiology of pancreatic cancer.

Authors:  L Gordis; E B Gold
Journal:  World J Surg       Date:  1984-12       Impact factor: 3.352

4.  Animal model of human disease. Carcinoma of the pancreas in azaserine-treated rats.

Authors:  D S Longnecker
Journal:  Am J Pathol       Date:  1981-10       Impact factor: 4.307

5.  Pancreatic growth and cell turnover in the rat fed raw soya flour.

Authors:  P S Oates; R G Morgan
Journal:  Am J Pathol       Date:  1982-08       Impact factor: 4.307

6.  Modification of pancreatic carcinogenesis in the hamster model. 2. The effect of partial pancreatectomy.

Authors:  P M Pour; T Donnelly; K Stepan; K Muffly
Journal:  Am J Pathol       Date:  1983-01       Impact factor: 4.307

7.  Fate of pancreatic nodules induced by raw soya flour in rats.

Authors:  E E McGuinness; R G Morgan; K G Wormsley
Journal:  Gut       Date:  1987       Impact factor: 23.059

Review 8.  Effects of soybean flour on the pancreas of rats.

Authors:  E E McGuinness; R G Morgan; K G Wormsley
Journal:  Environ Health Perspect       Date:  1984-06       Impact factor: 9.031

  8 in total

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