| Literature DB >> 560718 |
Abstract
Retinal pigment epithelium cultured from normal rats phagocytizes large amounts of rod outer segment fragments isolated from normal rats and from RCS rats with inherited retinal degeneration. Cultured RCS rat pigment epithelium rarely ingests outer segment material, although the cells extend cellular processes around fragments of either type. Both normal and RCS pigment epithelium phagocytize polystyrene spheres. This demonstrates that RCS rat pigment epithelial cells contain a defect in the mechanism for phagocytizing outer segments.Entities:
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Year: 1977 PMID： 560718 DOI： 10.1126/science.560718
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728