| Literature DB >> 560416 |
G R Irwin, R G Allen, H G Segal, A M Allen, J R Putnak, H G Cannon, F H Top.
Abstract
In a military population antibody to hepatitis B core antigen (anti-HBc) was found in 39% of acute hepatitis cases negative for hepatitis B surface antigen (HBS Ag) and in 96% of HBs Ag-positive cases. Persistence of antibody to HBs Ag (anti-HBs) in convalescent-phase sera was significantly greater (P less than 0.001) in individuals with acute HBs Ag-positive hepatitis B than in patients with clinical HBs Ag-negative hepatitis B. The prevalence of anti-HBc in the absence of HBs Ag, anti-HBs, and clinical disease was 3.2% in this military population. In longitudinal studies of hepatitis B infection, the presence of anti-HBc preceded anti-HBs and improved the ability to determine the onset of sublicnical infection. Anti-HBc is a useful serologic marker for the study of the epidemiology of hepatitis B and improves the efficiency of detection of hepatitis B virus infection.Entities:
Mesh：
Substances：
Year: 1977 PMID： 560416 DOI： 10.1093/infdis/136.1.31
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226