Literature DB >> 560179

Abnormal-pursuit eye movements in schizophrenia. Evidence for a genetic indicator.

P S Holzman, E Kringlen, D L Levy, L R Proctor, S J Haberman, N J Yasillo.   

Abstract

Disordered smooth-pursuit eye movements occur in a high percentage of schizophrenic patients and their first-degree relatives. A Test of the hypothesis that these disorders represent a genetic indicator of schizophrenia was undertaken by testing pursuit eye movements in a sample of monozygotic and dizygotic twins discordant for clinical schizophrenia. Deviant eye tracking is significantly concordant within monozygotic twin pairs, and less so with dizygotic twin pairs discordant for schizophrenia. A genetic interpretation is consistent with these results.

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Year:  1977        PMID: 560179     DOI: 10.1001/archpsyc.1977.01770190064005

Source DB:  PubMed          Journal:  Arch Gen Psychiatry        ISSN: 0003-990X


  18 in total

Review 1.  Eye tracking dysfunction in schizophrenia: characterization and pathophysiology.

Authors:  Deborah L Levy; Anne B Sereno; Diane C Gooding; Gilllian A O'Driscoll
Journal:  Curr Top Behav Neurosci       Date:  2010

2.  Neurobehavioral abnormalities in first-degree relatives of individuals with autism.

Authors:  Matthew W Mosconi; Margaret Kay; Anna-Maria D'Cruz; Stephen Guter; Kush Kapur; Carol Macmillan; Lisa D Stanford; John A Sweeney
Journal:  Arch Gen Psychiatry       Date:  2010-08

3.  Eye tracking in normal twins.

Authors:  W G Iacono
Journal:  Behav Genet       Date:  1982-09       Impact factor: 2.805

Review 4.  Genetics and schizophrenic behavior.

Authors:  E Kahn
Journal:  Psychiatr Q       Date:  1980

Review 5.  The use of eye movement dysfunctions in exploring the genetic transmission of schizophrenia.

Authors:  P S Holzman
Journal:  Eur Arch Psychiatry Neurol Sci       Date:  1989

6.  Flexibility of foveal attention during ocular pursuit.

Authors:  Stephen J Heinen; Zhenlan Jin; Scott N J Watamaniuk
Journal:  J Vis       Date:  2011-02-10       Impact factor: 2.240

7.  SPEM dysfunction and general schizotypy as measured by the SSQ: a controlled study.

Authors:  Dirk van Kampen; Jan Berend Deijen
Journal:  BMC Neurol       Date:  2009-06-29       Impact factor: 2.474

8.  Trait vs. State Markers for Schizophrenia: Identification and Characterization through Visual Processes.

Authors:  Yue Chen; L Cinnamon Bidwell; Daniel Norton
Journal:  Curr Psychiatry Rev       Date:  2006-11

9.  Eye movement dysfunction in first-degree relatives of patients with schizophrenia: a meta-analytic evaluation of candidate endophenotypes.

Authors:  Monica E Calkins; William G Iacono; Deniz S Ones
Journal:  Brain Cogn       Date:  2008-10-18       Impact factor: 2.310

Review 10.  Markers of vulnerability in schizophrenia.

Authors:  Maria Ladea; Dan Prelipceanu
Journal:  J Med Life       Date:  2009 Apr-Jun
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