| Literature DB >> 560035 |
B F Fell, R M Campbell, D Dinsdale.
Abstract
Daily treatment of female rats with medroxyprogesterone acetate in aqueous suspension resulted in adrenocortical atrophy. The doses given were those used for oestrus synchronisation. Intramuscular injections of 2-0 mg medroxyprogesterone acetate were used to investigate the atrophic process. Adrenocortical involution was associated with extensive single cell deletion (apoptosis). It is suggested that theses changes were due to suppression of pituitary ACTH secretion. The cytological changes support the concept that single cell death plays an important role in organ remodelling. Biochemical determinations of DNA, RNA, protein and dry matter, and histological examination, did not reveal significant changes in the liver.Entities:
Keywords: Adrenal Cortex Effects; Animals, Laboratory; Biology; Body Weight; Clinical Research; Contraception; Contraceptive Agents, Female--administraction and dosage; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--administraction and dosage; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--administraction and dosage; Contraceptive Agents--pharmacodynamics; Cytologic Effects; Endocrine Effects; Endocrine System; Family Planning; Hepatic Effects; Histology; Laboratory Procedures; Literature Review; Medroxyprogesterone Acetate--administraction and dosage; Medroxyprogesterone Acetate--pharmacodynamics; Physiology; Research Methodology
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Year: 1977 PMID： 560035
Source DB: PubMed Journal: Res Vet Sci ISSN： 0034-5288 Impact factor: 2.534