Literature DB >> 559966

Immunofluorescence study of brain plaques from two patients with multiple sclerosis.

J L Woyciechowska, W J Brzosko.   

Abstract

Immunofluorescence studies were performed on selected plaques from two multiple sclerosis patients. Positive staining revealed the corresponding presence of immunoglobulin G and complement fraction C1q within the plaque areas. These components could be removed only after low pH washing. On the basis of these observations, we discuss the possibility of the presence of immunocomplexes within the multiple sclerosis brain.

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Year:  1977        PMID： 559966     DOI： 10.1212/wnl.27.7.620

Source DB:  PubMed          Journal:  Neurology        ISSN： 0028-3878            Impact factor:   9.910


  11 in total

1.  Polyreactive myelin oligodendrocyte glycoprotein antibodies: Implications for systemic autoimmunity in progressive experimental autoimmune encephalomyelitis.

Authors:  Lisa K Peterson; Ikuo Tsunoda; Takahisa Masaki; Robert S Fujinami
Journal:  J Neuroimmunol       Date:  2007-01-02       Impact factor: 3.478

2.  Autoantibody-mediated demyelination depends on complement activation but not activatory Fc-receptors.

Authors:  Eduard Urich; Ilona Gutcher; Marco Prinz; Burkhard Becher
Journal:  Proc Natl Acad Sci U S A       Date:  2006-11-22       Impact factor: 11.205

3.  Cerebrospinal fluid in multiple sclerosis: relationships between immunoglobulins, leucocytes and clinical features.

Authors:  R W Walker; E J Thompson; W I McDonald
Journal:  J Neurol       Date:  1985       Impact factor: 4.849

Review 4.  B cells in multiple sclerosis.

Authors:  Mark P Burgoon; Donald H Gilden; Gregory P Owens
Journal:  Front Biosci       Date:  2004-01-01

5.  A specific immunofluorescence technique for the demonstration of vasogenic brain edema in paraffin embedded material.

Authors:  F Wilmes; K A Hossmann
Journal:  Acta Neuropathol       Date:  1979-01-12       Impact factor: 17.088

6.  The elution of IgG from subacute sclerosing panencephalitis and multiple sclerosis brains.

Authors:  C J Sindic; C L Cambiaso; P L Masson; E C Laterre
Journal:  Clin Exp Immunol       Date:  1980-07       Impact factor: 4.330

7.  Immune complexes in multiple sclerosis: relation to clinical pattern.

Authors:  U Patzold; P Haller; B Baruth; W Liman; H Deicher
Journal:  J Neurol       Date:  1980       Impact factor: 4.849

8.  Cross-reactive myelin antibody induces renal pathology.

Authors:  Lisa K Peterson; Takahisa Masaki; Steven R Wheelwright; Ikuo Tsunoda; Robert S Fujinami
Journal:  Autoimmunity       Date:  2008-11       Impact factor: 2.815

9.  Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis.

Authors:  R A Williamson; M P Burgoon; G P Owens; O Ghausi; E Leclerc; L Firme; S Carlson; J Corboy; P W Parren; P P Sanna; D H Gilden; D R Burton
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-06       Impact factor: 11.205

10.  IgG glycan hydrolysis by EndoS inhibits experimental autoimmune encephalomyelitis.

Authors:  Mahdia Benkhoucha; Nicolas Molnarfi; Marie-Laure Santiago-Raber; Martin S Weber; Doron Merkler; Mattias Collin; Patrice H Lalive
Journal:  J Neuroinflammation       Date:  2012-09-03       Impact factor: 8.322
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