Literature DB >> 5581289

6-thioguanine: antimitotic effect on human lymphocytes in vitro prevented by adenine.

D J Price, J Timson.   

Abstract

The action of 6-thioguanine on the division of PHA-stimulated human lymphocytes in vitro has been investigated and shown to have a definite antimitotic effect which is prevented by adenine but not by guanine or hypoxanthine. It is suggested that in this test system 6-TG exerts its main inhibitory action on phosphoribosylpyrophosphate amidotransferase.

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Year:  1971        PMID： 5581289      PMCID： PMC2008542          DOI： 10.1038/bjc.1971.15

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  6 in total

Review 1.  MECHANISMS OF RESISTANCE TO ANTICANCER AGENTS.

Authors:  R W BROCKMAN
Journal:  Adv Cancer Res       Date:  1963       Impact factor: 6.242

2.  PSEUDOFEEDBACK INHIBITION OF PURINE SYNTHESIS BY 6-MERCAPTOPURINE RIBONUCLEOTIDE AND OTHER PURINE ANALOGUES.

Authors:  R J MCCOLLISTER; W R GILBERT; D M ASHTON; J B WYNGAARDEN
Journal:  J Biol Chem       Date:  1964-05       Impact factor: 5.157

3.  REACTIONS OF RIBONUCLEOTIDE DERIVATIVES OF PURINE ANALOGUES AT THE CATALYTIC SITE OF INOSINE 5'-PHOSPHATE DEHYDROGENASE.

Authors:  A HAMPTON
Journal:  J Biol Chem       Date:  1963-09       Impact factor: 5.157

4.  Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents.

Authors:  H EAGLE; G E FOLEY
Journal:  Cancer Res       Date:  1958-10       Impact factor: 12.701

5.  Treatment of acute leukemia.

Authors:  J H BURCHENAL; M L MURPHY; C T TAN
Journal:  Pediatrics       Date:  1956-10       Impact factor: 7.124

6.  An hypothesis on the mechanism of action of 6-thioguanine.

Authors:  R P Miech; R E Parks; J H Anderson; A C Sartorelli
Journal:  Biochem Pharmacol       Date:  1967-11       Impact factor: 5.858
  6 in total
  1 in total

1.  Cellular reactions of O6-methylguanine, a product of some alkylating carcinogens.

Authors:  C T Miller; P D Lawley; S A Shah
Journal:  Biochem J       Date:  1973-10       Impact factor: 3.857
  1 in total

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