Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Enhancement of methyldopa metabolism with barbiturate.

Literature DB >> 5570647

Enhancement of methyldopa metabolism with barbiturate.

A Káldor, P Juvancz, M Demeczky, K Sebestyen, J Palotas.

Abstract

The spurious increase in serum catecholamine levels associated with methyldopa treatment can be reduced by the simultaneous administration of phenobarbitone. This accelerating effect of phenobarbitone on methyldopa metabolism has been demonstrated in relation to both adrenaline and noradrenaline, and investigations suggest that it is due to the effect of barbiturate on the activity of metabolizing enzymes.

Entities: Chemical

Mesh：

Substances：

Year: 1971 PMID： 5570647 PMCID： PMC1800466 DOI： 10.1136/bmj.3.5773.518

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

6 in total

1. THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS.

Authors: R P BUHS; J L BECK; O C SPETH; J L SMITH; N R TRENNER; P J CANNON; J H LARAGH
Journal: J Pharmacol Exp Ther Date: 1964-02 Impact factor: 4.030

2. Spurious elevation of urinary catecholamines during therapy with alpha-methyl-dopa. A diagnostic pitfall.

Authors: R W GIFFORD; D C TWEED
Journal: JAMA Date: 1962-10-27 Impact factor: 56.272

3. Thirty-minutes screening test for phaeochromocytoma.

Authors: D HINGERTY
Journal: Lancet Date: 1957-04-13 Impact factor: 79.321

4. Inhibition of dihydroxy-phenylalanine decarboxylase by derivatives of phenylalanine.

Authors: T L SOURKES
Journal: Arch Biochem Biophys Date: 1954-08 Impact factor: 4.013

5. Pharmacological implications of microsomal enzyme induction.

Authors: A H Conney
Journal: Pharmacol Rev Date: 1967-09 Impact factor: 25.468

6. DRUG INTERACTIONS IN MAN. I. LOWERING EFFECT OF PHENOBARBITAL ON PLASMA LEVELS OF BISHYDROXYCOUMARIN (DICUMAROL) AND DIPHENYLHYDANTOIN (DILANTIN).

Authors: S A CUCINELL; A H CONNEY; M SANSUR; J J BURNS
Journal: Clin Pharmacol Ther Date: 1965 Jul-Aug Impact factor: 6.875

6 in total

5 in total

Enhancement of methyldopa metabolism with barbiturate.

1. THE METABOLISM OF METHYLDOPA IN HYPERTENSIVE HUMAN SUBJECTS.

2. Spurious elevation of urinary catecholamines during therapy with alpha-methyl-dopa. A diagnostic pitfall.

3. Thirty-minutes screening test for phaeochromocytoma.

4. Inhibition of dihydroxy-phenylalanine decarboxylase by derivatives of phenylalanine.

5. Pharmacological implications of microsomal enzyme induction.

6. DRUG INTERACTIONS IN MAN. I. LOWERING EFFECT OF PHENOBARBITAL ON PLASMA LEVELS OF BISHYDROXYCOUMARIN (DICUMAROL) AND DIPHENYLHYDANTOIN (DILANTIN).

1. Barbiturates and methyldopa metabolism.

Review 2. Pharmacokinetic interactions with antiepileptic drugs.

Review 3. Clinical pharmacokinetics of methyldopa.

4. Epilepsy and pregnancy: a report from the Oxford Record Linkage Study.

5. Hair cortisol concentrations are associated with hippocampal subregional volumes in children.