Literature DB >> 556781

Induction of syncytia by Moloney murine leukemia virus in myoblasts defective in differentiation.

P K Wong, P H Yuen, S J Kaufman.   

Abstract

fu-1 cells, a nonfusing variant of the L8 line of rat myoblasts, form syncytia upon infection with murine leukemia virus (MuLV) or upon cocultivation with MuLV-infected cells; L8 cells do not form these syncytia, but do fuse into multinucleate myotubes. Syncytia of fu-1 cells form within 1 h after infection. The number of syncytia formed is proportional to the multiplicity of virus within a range of 4 to 16 and is maximum when the cell density is subconfluent. When either XC or fu-1 cells are productively infected with MuLV, they become resistant to syncytia formation by passage 3. The rapid formation of syncytia in fu-1 cells was found amenable for selection of temperature-sensitive mutants of MuLV and for screening additional variants of the L8 line.

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Mesh：

Year:  1977        PMID： 556781      PMCID： PMC353818     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  Studies on the budding process of a temperature-sensitive mutant of murine leukemia virus with a scanning electron microscope.

Authors:  P K Wong; R MacLeod
Journal:  J Virol       Date:  1975-08       Impact factor: 5.103

2.  Analysis of giant polynuclear cell formation caused by HVJ virus from Ehrlich's ascites tumor cells. I. Microscopic observation of giant polynuclear cell formation.

Authors:  Y OKADA
Journal:  Exp Cell Res       Date:  1962-02       Impact factor: 3.905

Review 3.  Membrane fusion.

Authors:  G Poste; A C Allison
Journal:  Biochim Biophys Acta       Date:  1973-12-28

4.  Lack of syncytium formation by a type C virus-producing XC cell line in the mixed culture cytopathogenicity test.

Authors:  J C Chan; N Vera; J L East; S Hiraki; L Dmochowski
Journal:  Cancer Res       Date:  1974-03       Impact factor: 12.701

5.  Formation of syncytia in human lymphoblastoid cells infected with type C viruses.

Authors:  B Hampar; K H Rand; R A Lerner; B C Del Villano; R M McAllister; L M Martos; J G Derge; C W Long; R V Gilden
Journal:  Virology       Date:  1973-10       Impact factor: 3.616

Review 6.  Mechanisms of virus-induced cell fusion.

Authors:  G Poste
Journal:  Int Rev Cytol       Date:  1972

7.  Syncytial assay for the putative human C-type virus, RD-114, utilizing human cells transformed by Rous sarcoma virus.

Authors:  K H Rand; C Long
Journal:  Nat New Biol       Date:  1972-12-06

8.  Studies of two temperature-sensitive mutants of Moloney murine leukemia virus.

Authors:  P K Wong; J A McCarter
Journal:  Virology       Date:  1974-04       Impact factor: 3.616

9.  Mixed culture cytopathogenicity: a new test for growth of murine leukemia viruses in tissue culture.

Authors:  V Klement; W P Rowe; J W Hartley; W E Pugh
Journal:  Proc Natl Acad Sci U S A       Date:  1969-07       Impact factor: 11.205

10.  ON THE STATISTICAL DISTRIBUTION OF EPIDERMAL PAPILLOMATA IN MICE.

Authors:  J K BALL; T Y HUH; J A MCCARTER
Journal:  Br J Cancer       Date:  1964-03       Impact factor: 7.640
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  11 in total

1.  Selective syncytium formation by murine leukemia virus in rat 3Y1 fibroblasts transformed by adenovirus type 12 or its E1A gene.

Authors:  N Momozaki; H Ogura; S Matsuhashi; K Joh; K Tabuchi; G Kimura; K Hori
Journal:  Arch Virol       Date:  1990       Impact factor: 2.574

2.  Mechanism of murine leukemia virus-induced fusion in rat myoblasts defective in differentiation.

Authors:  P K Wong; P H Yuen; S J Kaufman
Journal:  J Virol       Date:  1977-09       Impact factor: 5.103

3.  Preliminary characterization of a temperature-sensitive mutant of Moloney murine leukemia virus that produces particles at the restrictive temperature.

Authors:  P K Wong; G E Gallick
Journal:  J Virol       Date:  1978-01       Impact factor: 5.103

4.  In vivo evolution of a novel, syncytium-inducing and cytopathic feline leukemia virus variant.

Authors:  J L Rohn; M S Moser; S R Gwynn; D N Baldwin; J Overbaugh
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

5.  Effect of tunicamycin on cell fusion induced by Mason-Pfizer monkey virus.

Authors:  S Chatterjee; J Bradac; E Hunter
Journal:  J Virol       Date:  1981-05       Impact factor: 5.103

6.  Rapid syncytium formation induced by Moloney murine sarcoma virus in 3T3/NIH cells and its delay by mouse interferon.

Authors:  M Aboud; M Huleihel
Journal:  Arch Virol       Date:  1981       Impact factor: 2.574

7.  Cell fusion induced by the murine leukemia virus envelope glycoprotein.

Authors:  J S Jones; R Risser
Journal:  J Virol       Date:  1993-01       Impact factor: 5.103

8.  Early syncytium formation by bovine leukemia virus.

Authors:  D C Graves; L V Jones
Journal:  J Virol       Date:  1981-06       Impact factor: 5.103

9.  Loss of growth control and differentiation in the fu-1 variant of the L8 line of rat myoblasts.

Authors:  S J Kaufman; C M Parks
Journal:  Proc Natl Acad Sci U S A       Date:  1977-09       Impact factor: 11.205

10.  N-Linked glycosylation is required for XC cell-specific syncytium formation by the R peptide-containing envelope protein of ecotropic murine leukemia viruses.

Authors:  Yoshinao Kubo; Akinori Ishimoto; Hiroshi Amanuma
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103
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