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Literature DB >> 5564400

Progeria: a cell culture study on aging.

Abstract

Progeria is an autosomal recessive disorder showing precocious senility. The cultured skin fibroblast from both the homozygous affected individual and the heterozygous parents can be distinguished from normals by decreased cell growth in culture. Mitotic activity, DNA synthesis, and cloning efficiency are markedly reduced.

Entities: Disease

Mesh：

Substances：
Tritium
DNA
Thymidine

Year: 1971 PMID： 5564400 PMCID： PMC292126 DOI： 10.1172/JCI106692

Source DB: PubMed Journal: J Clin Invest ISSN： 0021-9738 Impact factor: 14.808

15 in total

1. Human chromosome complements in normal somatic cells in culture.

Authors: E H CHU; N H GILES
Journal: Am J Hum Genet Date: 1959-03 Impact factor: 11.025

2. Lifespan of cultured cells in progeria.

Authors: S Goldstein
Journal: Lancet Date: 1969-02-22 Impact factor: 79.321

3. Viability of human diploid cells as a function of in vitro age.

Authors: G S Merz; J D Ross
Journal: J Cell Physiol Date: 1969-12 Impact factor: 6.384

4. Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.

Authors: D Hughes; E A Caspary
Journal: Int Arch Allergy Appl Immunol Date: 1970

Review 5. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.

Authors: C J Epstein; G M Martin; A L Schultz; A G Motulsky
Journal: Medicine (Baltimore) Date: 1966-05 Impact factor: 1.889

6. Werner's syndrome; caricature of aging. A genetic model for the study of degenerative diseases.

Authors: C J Epstein; G M Martin; A G Motulsky
Journal: Trans Assoc Am Physicians Date: 1965

7. Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

Authors: G M Martin; C A Sprague; C J Epstein
Journal: Lab Invest Date: 1970-07 Impact factor: 5.662

8. Diabetes mellitus and aging: diminished planting efficiency of cultured human fibroblasts.

Authors: S Goldstein; J W Littlefield; J S Soeldner
Journal: Proc Natl Acad Sci U S A Date: 1969-09 Impact factor: 11.205

9. Cystic fibrosis of the pancreas. A study in cell culture.

Authors: B S Danes; A G Bearn
Journal: J Exp Med Date: 1969-04-01 Impact factor: 14.307

10. Hurler's syndrome. A genetic study in cell culture.

Authors: B S Danes; A G Bearn
Journal: J Exp Med Date: 1966-01-01 Impact factor: 14.307

12 in total

1. Progeria in twins.

Authors: J Viégas; P L Souza; F M Salzano
Journal: J Med Genet Date: 1974-12 Impact factor: 6.318

2. Absence of detectable HL-A antigens on cultured fibroblasts in progeria.

Authors: D P Singal; S Goldstein
Journal: J Clin Invest Date: 1973-09 Impact factor: 14.808

3. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo.

Authors: D Röhme
Journal: Proc Natl Acad Sci U S A Date: 1981-08 Impact factor: 11.205

Progeria: a cell culture study on aging.

1. Human chromosome complements in normal somatic cells in culture.

2. Lifespan of cultured cells in progeria.

3. Viability of human diploid cells as a function of in vitro age.

4. Lymphocyte transformation in vitro measured by tritiated thymidine uptake. I. Lymphocyte culture techniques.

Review 5. Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process.

6. Werner's syndrome; caricature of aging. A genetic model for the study of degenerative diseases.

7. Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotype.

8. Diabetes mellitus and aging: diminished planting efficiency of cultured human fibroblasts.

9. Cystic fibrosis of the pancreas. A study in cell culture.

10. Hurler's syndrome. A genetic study in cell culture.

1. Progeria in twins.

2. Absence of detectable HL-A antigens on cultured fibroblasts in progeria.

3. Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo.

4. Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation.

5. Progeria: a cell culture study and clinical report of familial incidence.

6. A new familial intrauterine growth retardation syndrome the "3-M syndrome".

7. Heat-labile enzymes in circulating erythrocytes of a progeria family.

8. Deficient DNA repair in human progeroid cells.

Review 9. Redox control of signal transduction, gene expression and cellular senescence.

10. Hypoparathyroidism in an Egyptian child with Hutchinson-Gilford progeria syndrome: a case report.