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Literature DB >> 556069

Swelling and contraction of heart mitochondria suspended in ammonium phosphate.

Abstract

Bovine heart mitochondria which have been allowed to swell in isotonic NH4+ phosphate contract in response to initiation of oxidative phosphorylation. The contraction occurs optimally at pH 6.0 and appears from inhibition studies to result from Pi uptake being slower than removal of internal Pi via phosphorylation of external ADP. Similar results are obtained when K+ + nigericin is substituted for NH4+. Mersalyl inhibition of Pi transport in respiring, nonphosphorylating mitochondria which have been allowed to swell in NH4+ phosphate reveals a contractile process having an alkaline pH optimum. This contraction resembles closely the contraction observed in salts of strong acids and presumably occurs by electrophoretic ejection of Pi anions driven by electrogenic H+ ejection.

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Year: 1978 PMID： 556069 DOI： 10.1007/bf00743053

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

28 in total

6. Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria.

Authors: C R Hackenbrock
Journal: J Cell Biol Date: 1966-08 Impact factor: 10.539

10. Osmotically-induced alterations in volume and ultrastructure of mitochondria isolated from rat liver and bovine heart.

Authors: C D Stoner; H D Sirak
Journal: J Cell Biol Date: 1969-12 Impact factor: 10.539

2 in total

1. The role of Mg2+ in the regulation of the structural and functional steady-states in rat liver mitochondria.

Authors: A Masini; D Ceccarelli-Stanzani; U Muscatello
Journal: J Bioenerg Biomembr Date: 1983-08 Impact factor: 2.945

2. Steady-state kinetics of the overall oxidative phosphorylation reaction in heart mitochondria. Evidence for linkage of the energy-yielding and energy-consuming steps by freely diffusible intermediates and for an allosteric mechanism of respiratory control at coupling site 2.

Authors: C D Stoner
Journal: J Bioenerg Biomembr Date: 1985-04 Impact factor: 2.945

2 in total

Swelling and contraction of heart mitochondria suspended in ammonium phosphate.

Review 1. H+-Adenosine triphosphatase and membrane energy coupling.

2. CALCIUM ION ACCUMULATION AND VOLUME CHANGES OF ISOLATED LIVER MITOCHONDRIA. REVERSAL OF CALCIUM ION-INDUCED SWELLING.

3. Antibiotic-mediated transport of alkali ions across lipid barriers.

4. Oxidative phosphorylation in mitochondria isolated from chronically stressed dog hearts.

5. Translocation of some anions cations and acids in rat liver mitochondria.

6. Ultrastructural bases for metabolically linked mechanical activity in mitochondria. I. Reversible ultrastructural changes with change in metabolic steady state in isolated liver mitochondria.

7. Mechanism of active shrinkage in mitochondria. I. Coupling between weak electrolyte fluxes.

8. Functioning of the adenine nucleotide transporter in the arsenate uncoupling of corn mitochondria.

9. ROLE OF EDTA AND METALS IN MITOCHONDRIAL CONTRACTION.

10. Osmotically-induced alterations in volume and ultrastructure of mitochondria isolated from rat liver and bovine heart.

1. The role of Mg2+ in the regulation of the structural and functional steady-states in rat liver mitochondria.

2. Steady-state kinetics of the overall oxidative phosphorylation reaction in heart mitochondria. Evidence for linkage of the energy-yielding and energy-consuming steps by freely diffusible intermediates and for an allosteric mechanism of respiratory control at coupling site 2.