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Literature DB >> 5558354

The accumulation of ( 14 C)5-hydroxyindol-3-ylacetic acid by the rabbit choroid plexus in vitro.

Abstract

1. The lateral and fourth ventricular choroid plexuses of the rabbit have been shown to be capable of the in vitro accumulation of 5-hydroxyindol-3-ylacetic acid (5-HIAA).2. The accumulation of 5-HIAA occurs against a concentration gradient and is dependent on metabolic energy.3. It is possible to inhibit the accumulation of 5-HIAA by the presence of the dopamine metabolite, 3-methoxy-4-hydroxyphenylacetic acid (HVA) or of probenecid in the incubation medium.4. It would appear that the characteristics of the accumulation of 5-HIAA by the isolated choroid plexuses are consistent with the involvement of this tissue in the in vivo active transfer of 5-HIAA from the c.s.f. to the blood.

Entities: Chemical Disease Species

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Year: 1971 PMID： 5558354 PMCID： PMC1331969 DOI： 10.1113/jphysiol.1971.sp009518

Source DB: PubMed Journal: J Physiol ISSN： 0022-3751 Impact factor: 5.182

15 in total

10. The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetized dog.

Authors: G W Ashcroft; R C Dow; A T Moir
Journal: J Physiol Date: 1968-12 Impact factor: 5.182

2 in total

1. 5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis and the effect of probenecid treatment.

Authors: R Sjöström
Journal: Eur J Clin Pharmacol Date: 1973-08 Impact factor: 2.953

2. Cellular localization of the uptake of 5-hydroxytryptamine in the area postrema of the rabbit after injection into a lateral ventricle.

Authors: R C Dow; I Laszlo; I M Ritchie
Journal: Br J Pharmacol Date: 1973-12 Impact factor: 8.739

2 in total

The accumulation of ( 14 C)5-hydroxyindol-3-ylacetic acid by the rabbit choroid plexus in vitro.

1. The passage of certain substances out of the cerebrosphinal fluid.

2. Quantitative studies of the passage of different substances out of the cerebrospinal fluid.

3. Active transport of Diodrast and phenolsulfonphthalein from cerebrospinal fluid to blood.

4. Renal metabolism of 5-hydroxyindolacetic acid.

5. Transport of narcotic analgesics by choroid plexus and kidney tissue in vitro.

6. Transport of sulphate, thiosulphate and iodide by choroid plexus in vitro.

7. Amino acid transport by choroid plexus in vitro.

8. Transport of serotonin and norepinephrine by the rabbit choroid plexus in vitro.

9. Studies on the uptake of morphine by the choroid plexus in vitro.

10. The active transport of 5-hydroxyindol-3-ylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid from a recirculatory perfusion system of the cerebral ventricles of the unanaesthetized dog.

1. 5-Hydroxyindole acetic acid and homovanillic acid in cerebrospinal fluid in manic-depressive psychosis and the effect of probenecid treatment.

2. Cellular localization of the uptake of 5-hydroxytryptamine in the area postrema of the rabbit after injection into a lateral ventricle.