| Literature DB >> 5547729 |
H D Christensen, R I Freudenthal, J T Gidley, R Rosenfeld, G Boegli, L Testino, D R Brine, C G Pitt, M E Wall.
Abstract
The 11-hydroxy metabolites of Delta(8).- and Delta(9)-tetrahydrocannabinol are more active than the parent compounds when administered to mice by either the intravenous or intracerebral route. Both Delta(8)- and Delta(9)-tetrahydrocannabinol are rapidly and extensively metabolized by the liver and not by the brain. The hypothesis that the 11-hydroxy metabolites may be the active form of tetrahydrocannabinol is discussedEntities:
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Year: 1971 PMID： 5547729 DOI： 10.1126/science.172.3979.165
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728