Literature DB >> 5546289

Cycloheximide: its effects on activity are dissociable from its effects on memory.

D S Segal, L R Squire, S H Barondes.   

Abstract

Cycloheximide, when injected subcutaneously or intracerebrally, produces changes in the activity level of mice. Isocycloheximide, injected intracerebrally, produces identical effects on activity, but it does not produce inhibition of cerebral protein synthesis or amnesia. Amphetamine, in doses that can antagonize the amnesic action of cycloheximide, does not antagonize the effect of cycloheximide on activity. Effects of cycloheximide on activity do not appear to be responsible for its amnesic action.

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Year:  1971        PMID： 5546289     DOI： 10.1126/science.172.3978.82

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  7 in total

1.  A role for α-adducin (ADD-1) in nematode and human memory.

Authors:  Vanja Vukojevic; Leo Gschwind; Christian Vogler; Philippe Demougin; Dominique J-F de Quervain; Andreas Papassotiropoulos; Attila Stetak
Journal:  EMBO J       Date:  2012-02-03       Impact factor: 11.598

2.  The effects of the protein synthesis inhibitor anisomycin on the febrile responses to intracerebroventricular injections of bacterial pyrogen, arachidonic acid and prostaglandin E2.

Authors:  A S Milton; V K Sawhney
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1987-09       Impact factor: 3.000

Review 3.  Role of RNA and protein in memory storage: a review.

Authors:  L L Uphouse; J W MacInnes; K Schlesinger
Journal:  Behav Genet       Date:  1974-03       Impact factor: 2.805

4.  Changing the actions of neuroactive drugs by changing brain protein synthesis.

Authors:  L C Tang; G C Cotzias; M Dunn
Journal:  Proc Natl Acad Sci U S A       Date:  1974-09       Impact factor: 11.205

Review 5.  Pharming for Genes in Neurotransmission: Combining Chemical and Genetic Approaches in Caenorhabditis elegans.

Authors:  Stephen M Blazie; Yishi Jin
Journal:  ACS Chem Neurosci       Date:  2018-03-06       Impact factor: 4.418

6.  Variable decay of memory and its recovery in cycloheximide-treated mice.

Authors:  L R Squire; S H Barondes
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

7.  The effects of various protein synthesis inhibitors on the sleep-wake cycle of rats.

Authors:  J A Rojas-Ramírez; E Aguilar-Jiménez; A Posadas-Andrews; J G Bernal-Pedraza; R R Drucker-Colín
Journal:  Psychopharmacology (Berl)       Date:  1977-07-18       Impact factor: 4.530
  7 in total

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