Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Treatment of Paget's disease of bone with mithramycin.

Literature DB >> 5543993

Treatment of Paget's disease of bone with mithramycin.

J R Condon, S B Reith, J R Nassim, F J Millard, A Hilb, E M Stainthorpe.

Abstract

We report data from three patients with severe Paget's disease of bone who were treated with mithramycin.Mithramycin infusion resulted in a fall in plasma calcium, phosphate, alkaline phosphatase, and urinary hydroxyproline excretion. There was an improvement in calcium and phosphorus balance in two of the three subjects studied. A pronounced or complete relief of bone pain occurred in all three.We suggest that mithramycin exerts its beneficial effect in Paget's disease of bone by stimulating parathyroid hormone release. The parathyroid hormone released has a predominantly anabolic action on bone since its catabolic action is blocked by mithramycin, which inhibits bone resorption.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1971 PMID： 5543993 PMCID： PMC1795078 DOI： 10.1136/bmj.1.5746.421

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

12 in total

1. MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED CANCER.

Authors: S KOFMAN; R EISENSTEIN
Journal: Cancer Chemother Rep Date: 1963-10

2. EFFECT OF SODIUM FLUORIDE ON CALCIUM, PHOSPHORUS, AND NITROGEN BALANCE IN PATIENTS WITH PAGET'S DISEASE.

Authors: B A HIGGINS; J R NASSIM; R ALEXANDER; A HILB
Journal: Br Med J Date: 1965-05-01

3. The suppression of Paget's disease with ACTH and cortisone.

Authors: F ALBRIGHT; P H HENNEMAN
Journal: Trans Assoc Am Physicians Date: 1955

4. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine.

Authors: P R KIND; E J KING
Journal: J Clin Pathol Date: 1954-11 Impact factor: 3.411

5. The local action of the parathyroid and other tissues on bone in intracerebral grafts.

Authors: N A Barnicot
Journal: J Anat Date: 1948-10 Impact factor: 2.610

6. Effects of calcitonin on patients with Paget's disease, thyrotoxicosis, or hypercalcaemia.

Authors: O L Bijvoet; J van der Sluys Veer; A P Jansen
Journal: Lancet Date: 1968-04-27 Impact factor: 79.321

Review 7. Mode of action of antibiotics. II. Drugs affecting nucleic acid and protein synthesis.

Authors: I H Goldberg
Journal: Am J Med Date: 1965-11 Impact factor: 4.965

8. Role of magnesium metabolism and the effects of fluoride therapy in Paget's disease of bone.

Authors: L V Avioli; M Berman
Journal: J Clin Endocrinol Metab Date: 1968-05 Impact factor: 5.958

9. Effects of mithramycin on Paget's disease of bone.

Authors: W G Ryan; T B Schwartz; C P Perlia
Journal: Ann Intern Med Date: 1969-03 Impact factor: 25.391

10. Effect of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease.

Authors: V Parsons; M Baum; M Self
Journal: Br Med J Date: 1967-02-25

11 in total

1. Medical staff conference. Paget disease of bone.

Authors:
Journal: West J Med Date: 1978-09

2. Clinical and biochemical studies of Paget's disease of bone with emphasis on the effects of RNA inhibitors actinomycin D and mithrawycin.

Authors: J J Fennelly
Journal: Ir J Med Sci Date: 1971-10 Impact factor: 1.568

Treatment of Paget's disease of bone with mithramycin.

1. MITHRAMYCIN IN THE TREATMENT OF DISSEMINATED CANCER.

2. EFFECT OF SODIUM FLUORIDE ON CALCIUM, PHOSPHORUS, AND NITROGEN BALANCE IN PATIENTS WITH PAGET'S DISEASE.

3. The suppression of Paget's disease with ACTH and cortisone.

4. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine.

5. The local action of the parathyroid and other tissues on bone in intracerebral grafts.

6. Effects of calcitonin on patients with Paget's disease, thyrotoxicosis, or hypercalcaemia.

Review 7. Mode of action of antibiotics. II. Drugs affecting nucleic acid and protein synthesis.

8. Role of magnesium metabolism and the effects of fluoride therapy in Paget's disease of bone.

9. Effects of mithramycin on Paget's disease of bone.

10. Effect of mithramycin on calcium and hydroxyproline metabolism in patients with malignant disease.

1. Medical staff conference. Paget disease of bone.

2. Clinical and biochemical studies of Paget's disease of bone with emphasis on the effects of RNA inhibitors actinomycin D and mithrawycin.

Review 3. Drugs for disorders of bone: pharmacological and clinical considerations.

4. Compression of cord by Paget's disease.

5. Paget's disease of bone.

6. Clinical use of immunosuppressive drugs: part II.

7. Mithramycin therapy in Paget's disease.

8. Treatment of Paget's disease of bone with synthetic salmon calcitonin.

9. Control of osteitis deformans using glucagon, calcitonin, and mithramycin.

10. Relative importance of renal failure and increased bone resorption in the hypercalcaemia of myelomatosis.