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Literature DB >> 5543370

Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change.

B Lewis, B C Morson, A W February, J H Jones, J J Misiewicz.

Abstract

The isoenzyme pattern of lactic dehydrogenase was measured in rectal biopsies from six patients with ulcerative colitis in whom precancerous histological changes had been independently recognized. There was a highly significant increase in the ratio of isoenzymes IV + V to I + II. This suggests that lactic dehydrogenase isoenzyme measurement may prove a valuable addition to histology in the recognition of precancer in ulcerative colitis.

Entities: Disease Species

Mesh：

Year: 1971 PMID： 5543370 PMCID： PMC1411463 DOI： 10.1136/gut.12.1.16

Source DB: PubMed Journal: Gut ISSN： 0017-5749 Impact factor: 23.059

11 in total

1. THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS.

Authors: F C EDWARDS; S C TRUELOVE
Journal: Gut Date: 1964-02 Impact factor: 23.059

2. Carcinoma and ulcerative colitis, a clinical-pathologic study. II. Statistical analysis.

Authors: M B GOLDGRABER; E M HUMPHREYS; J B KIRSNER; W L PALMER
Journal: Gastroenterology Date: 1958-05 Impact factor: 22.682

3. Enzyme and isoenzyme studies in preinvasive carcinoma of the cervix.

Authors: A L Latner; D M Turner; S A Way
Journal: Lancet Date: 1966-10-15 Impact factor: 79.321

4. Lactate dehydrogenase isoenzymes in the diagnosis of human benign and malignant brain tumors.

Authors: W Gerhardt; J Clausen; E Christensen; J Riishede
Journal: J Natl Cancer Inst Date: 1967-03 Impact factor: 13.506

5. Lactate dehydrogenase isoenzyme patterns in the tumour-bearing colon.

Authors: E Langvad
Journal: Int J Cancer Date: 1968-01-15 Impact factor: 7.396

6. Some characteristics of lactate dehydrogenase isoenzymes in tumours of the female genital tract.

Authors: B H Stagg; G A Whyley
Journal: Clin Chim Acta Date: 1968-12 Impact factor: 3.786

7. The influence of cytostatic treatment on serum LDH patterns of patients with bronchial carcinoma and its relation to tumor regression.

Authors: R J Wieme; W Z Van Hove; M E Van der Straeten
Journal: Ann N Y Acad Sci Date: 1968-06-14 Impact factor: 5.691

1. Frontiers in inflammatory bowel disease. The proceedings of a conference sponsored by the McReynolds Foundation. Part II.

Authors: R G Shorter; D A Shephard
Journal: Am J Dig Dis Date: 1975-07

2. [Precancerous epithelial dysplasia in ulcerative colitis. Histological possibility for the early diagnosis of colitis carcinoma (author's transl)].

Authors: H F Otto; J O Gebbers
Journal: Virchows Arch A Pathol Anat Histol Date: 1978-03-10

3. Modern approaches to early identification of large-bowel cancer. Prospects for newer methodologies.

Authors: P Sherlock; S J Winawer
Journal: Am J Dig Dis Date: 1974-10

4. Adenomatous epithelium, intraepithelial anaplasia, and invasive carcinoma in ulcerative colitis.

Authors: C M Fenoglio; R R Pascal
Journal: Am J Dig Dis Date: 1973-07

5. Changes in composition of mucin in the mucosa adjacent to carcinoma of the colon as compared with the normal: a biochemical investigation.

Authors: M I Filipe; K B Cooke
Journal: J Clin Pathol Date: 1974-04 Impact factor: 3.411

Abnormal lactic dehydrogenase isoenzyme patterns in ulcerative colitis with precancerous change.

1. THE COURSE AND PROGNOSIS OF ULCERATIVE COLITIS. III. COMPLICATIONS.

2. Carcinoma and ulcerative colitis, a clinical-pathologic study. II. Statistical analysis.

3. Enzyme and isoenzyme studies in preinvasive carcinoma of the cervix.

4. Lactate dehydrogenase isoenzymes in the diagnosis of human benign and malignant brain tumors.

5. Lactate dehydrogenase isoenzyme patterns in the tumour-bearing colon.

6. Some characteristics of lactate dehydrogenase isoenzymes in tumours of the female genital tract.

7. The influence of cytostatic treatment on serum LDH patterns of patients with bronchial carcinoma and its relation to tumor regression.

8. Lactic dehydrogenase heterogeneity in the inflamed appendix.

9. Rectal biopsy as an aid to cancer control in ulcerative colitis.

10. Serum lactic acid dehydrogenase isoenzyme patterns in ulcerative colitis.

1. Frontiers in inflammatory bowel disease. The proceedings of a conference sponsored by the McReynolds Foundation. Part II.

2. [Precancerous epithelial dysplasia in ulcerative colitis. Histological possibility for the early diagnosis of colitis carcinoma (author's transl)].

3. Modern approaches to early identification of large-bowel cancer. Prospects for newer methodologies.

4. Adenomatous epithelium, intraepithelial anaplasia, and invasive carcinoma in ulcerative colitis.

5. Changes in composition of mucin in the mucosa adjacent to carcinoma of the colon as compared with the normal: a biochemical investigation.

6. Pathology of ulcerative colitis.

Review 7. The place of clinical chemistry in the detection of cancer.

8. Studies of lactic dehydrogenase content in rectal mucosal biopsies.

9. Cancer in chronic ulcerative colitis. Diagnostic role of segmental colonic lavage.

10. Lactate dehydrogenase isoenzyme pattern in uninvolved mucosa of patients with colorectal carcinoma.