Literature DB >> 5541655

Ethacrynic acid effect on the composition of cochlear fluids.

E S Cohn, E H Gordes, S W Brusilow.   

Abstract

Ethacrynic acid, when administered to six dogs, caused a fall in the concentration of potassium in endolymph from 145 to 21 milliequivalents per liter and a rise in the concentration of sodium from 5.9 to 146 milliequivalents per liter. The composition of perilymph is unaffected. Perilymph and endolymph are slightly hypertonic as compared to plasma.

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Year:  1971        PMID： 5541655     DOI： 10.1126/science.171.3974.910

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  8 in total

Review 1.  Diuretics: mechanism of action and clinical application.

Authors:  D L Davies; G M Wilson
Journal:  Drugs       Date:  1975       Impact factor: 9.546

2.  Inhibition of adenylate-cyclase-coupled G protein complex by ototoxic diuretics and cis-platinum in the inner ear of the guinea pig.

Authors:  T Koch; B Gloddek
Journal:  Eur Arch Otorhinolaryngol       Date:  1991       Impact factor: 2.503

3.  Differential effects of ouabain and ethacrynic acid on the labyrinthine potentials.

Authors:  P M Sellick; B M Johnstone
Journal:  Pflugers Arch       Date:  1974       Impact factor: 3.657

4.  The mutual independence of the endolymphatic potential and the concentrations of sodium and potassium in endolymph.

Authors:  S W Brusilow; E Gordes
Journal:  J Clin Invest       Date:  1973-10       Impact factor: 14.808

5.  Simultaneous investigations of elemental changes in individual cells of the stria vascularis and in endolymph.

Authors:  M Anniko; R Wróblewski
Journal:  Arch Otorhinolaryngol       Date:  1988

6.  Furosemide and ethacrynic acid in acute tubular necrosis.

Authors:  D W Nierenberg
Journal:  West J Med       Date:  1980-08

7.  The effects of intracochlear and systemic furosemide on the properties of single cochlear nerve fibres in the cat.

Authors:  E F Evans; R Klinke
Journal:  J Physiol       Date:  1982-10       Impact factor: 5.182

8.  Combined effects of noise and ototoxic drugs.

Authors:  S A Falk
Journal:  Environ Health Perspect       Date:  1972-10       Impact factor: 9.031
  8 in total

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