Literature DB >> 5539179

A within-patient comparison of debrisoquine and methyldopa in hypertension.

A Heffernan, A Carty, K O'Malley, J Bugler.   

Abstract

In a titrated dose cross-over trial of debrisoquine and methyldopa in 38 hypertensive patients neither drug was superior in lowering supine or standing diastolic pressure with a minimum of side effects. Methyldopa caused significantly greater reduction of supine (P<0.001) and standing (P<0.02) systolic pressure but caused intolerable side effects in two patients. Tiredness was the most characteristic and troublesome side effect with methyldopa and postural hypotension was prominent in patients while on debrisoquine.

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Year:  1971        PMID： 5539179      PMCID： PMC1795720          DOI： 10.1136/bmj.1.5740.75

Source DB:  PubMed          Journal:  Br Med J        ISSN： 0007-1447


  4 in total

1.  A SPHYGMOMANOMETER FOR EPIDEMIOLOGISTS.

Authors:  G A ROSE; W W HOLLAND; E A CROWLEY
Journal:  Lancet       Date:  1964-02-08       Impact factor: 79.321

2.  Bethanidine, Guanethidine, and Methyldopa in Treatment of Hypertension: a Within-patient Comparison.

Authors:  B N Prichard; A W Johnston; I D Hill; M L Rosenheim
Journal:  Br Med J       Date:  1968-01-20

3.  Debrisoquine--a hypotensive drug with minimal side-effects.

Authors:  A E Gent; A P Bacon
Journal:  Practitioner       Date:  1967-05

4.  Antagonism of the hypotensive action of bethanidine and debrisoquine by tricyclic antidepressants.

Authors:  C Skinner; D C Coull; A W Johnston
Journal:  Lancet       Date:  1969-09-13       Impact factor: 79.321
  4 in total
  5 in total

1.  Problems with Beta Adrenergic Blocking Drugs and other Antihypertensive Drugs.

Authors:  B N Prichard
Journal:  Proc R Soc Med       Date:  1977

Review 2.  The second Lilly Prize Lecture, University of Newcastle, July 1977. beta-Adrenergic receptor blockade in hypertension, past, present and future.

Authors:  B N Prichard
Journal:  Br J Clin Pharmacol       Date:  1978-05       Impact factor: 4.335

3.  Methyldopa hepatitis. Report of three cases.

Authors:  A M Hoyumpa; A M Connell
Journal:  Am J Dig Dis       Date:  1973-03

4.  Comparison of debrisoquine and guanethidine in treatment of hypertension.

Authors:  F C Adi; C J Eze; A Anwunah
Journal:  Br Med J       Date:  1975-03-01

5.  Importance of Publishing Adverse Drug Reaction Case Reports: Promoting Public Health and Advancing Pharmacology and Therapeutics.

Authors:  Rashmi R Shah
Journal:  Drug Saf Case Rep       Date:  2017-09-20
  5 in total

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