Literature DB >> 553830

Study on compounds with potential antitumor activity. III. Hydrazone derivatives of 5-substituted 2-chloro-3-formyl-6-methylindole.

A Andreani, M Rambaldi, D Bonazzi, L Greci, F Andreani.   

Abstract

The synthesis of 5-methoxy- (IX) and 5-hydroxy- (X) 2-chloro-3-formyl-6-methylindole is reported: three hydrazonic derivatives were prepared from each compound. Preliminary results on the activity of the six derivatives against P388 leukemia in mice are reported.

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Year:  1979        PMID： 553830     DOI： 10.1002/chin.197924211

Source DB:  PubMed          Journal:  Farmaco Sci        ISSN： 0430-0920


  4 in total

1.  Substituted 3-(5-imidazo[2,1-b]thiazolylmethylene)-2-indolinones and analogues: synthesis, cytotoxic activity, and study of the mechanism of action.

Authors:  Aldo Andreani; Massimiliano Granaiola; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Lucilla Varoli; Natalia Calonghi; Concettina Cappadone; Giovanna Farruggia; Claudio Stefanelli; Lanfranco Masotti; Tam L Nguyen; Ernest Hamel; Robert H Shoemaker
Journal:  J Med Chem       Date:  2012-02-15       Impact factor: 7.446

2.  Antitumor activity of bis-indole derivatives.

Authors:  Aldo Andreani; Silvia Burnelli; Massimiliano Granaiola; Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Lucilla Varoli; Laura Landi; Cecilia Prata; Michael V Berridge; Carole Grasso; Heinz-Herbert Fiebig; Gerhard Kelter; Angelika M Burger; Mark W Kunkel
Journal:  J Med Chem       Date:  2008-07-04       Impact factor: 7.446

3.  Substituted E-3-(3-indolylmethylene)-1,3-dihydroindol-2-ones with antitumor activity. In depth study of the effect on growth of breast cancer cells.

Authors:  Aldo Andreani; Stefania Bellini; Silvia Burnelli; Massimiliano Granaiola; Alberto Leoni; Alessandra Locatelli; Rita Morigi; Mirella Rambaldi; Lucilla Varoli; Natalia Calonghi; Concettina Cappadone; Maddalena Zini; Claudio Stefanelli; Lanfranco Masotti; Robert H Shoemaker
Journal:  J Med Chem       Date:  2010-08-12       Impact factor: 7.446

4.  Synthesis, evaluation of antioxidant activity and crystal structure of 2,4-dimethylbenzoylhydrazones.

Authors:  Muhammad Taha; Nor Hadiani Ismail; Waqas Jamil; Sammer Yousuf; Faridahanim Mohd Jaafar; Muhammad Imran Ali; Syed Muhammad Kashif; Ejaz Hussain
Journal:  Molecules       Date:  2013-09-05       Impact factor: 4.411
  4 in total

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