Literature DB >> 553332

High performance liquid chromatographic assay of vancomycin in serum.

J R Uhl, J P Anhalt.   

Abstract

A liquid chromatographic procedure is described for rapid and accurate quantitation of vancomycin in serum. Vancomycin is extracted from serum by using a CM-Sephadex column and is measured by reversed-phase chromatography with detection by UV absorption. Ristocetin is used as an internal standard. Concentration and instrument response are linearly related in the range of therapeutically useful concentrations. Results correlate well with those obtained by bioassay. The between-day coefficient of variation (n = 8) was less than 4%. Recovery of vancomycin from serum is nearly complete, and no substances that interfere with the procedure have been detected in clinical specimens.

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Year:  1979        PMID： 553332     DOI： 10.1097/00007691-197901000-00008

Source DB:  PubMed          Journal:  Ther Drug Monit        ISSN： 0163-4356            Impact factor:   3.681


  7 in total

1.  Pharmacokinetics and serum bactericidal activity of vancomycin alone and in combination with ceftazidime in healthy volunteers.

Authors:  M Boeckh; H Lode; K Borner; G Höffken; J Wagner; P Koeppe
Journal:  Antimicrob Agents Chemother       Date:  1988-01       Impact factor: 5.191

2.  Determination of vancomycin in human serum by high-pressure liquid chromatography.

Authors:  F Jehl; C Gallion; R C Thierry; H Monteil
Journal:  Antimicrob Agents Chemother       Date:  1985-04       Impact factor: 5.191

3.  Comparison of radioimmunoassay and fluorescent polarization immunoassay for quantitative determination of vancomycin concentrations in serum.

Authors:  B H Ackerman; H G Berg; R G Strate; J C Rotschafer
Journal:  J Clin Microbiol       Date:  1983-10       Impact factor: 5.948

4.  Laboratory evaluation of five assay methods for vancomycin: bioassay, high-pressure liquid chromatography, fluorescence polarization immunoassay, radioimmunoassay, and fluorescence immunoassay.

Authors:  M A Pfaller; D J Krogstad; G G Granich; P R Murray
Journal:  J Clin Microbiol       Date:  1984-09       Impact factor: 5.948

5.  Sensitive radioimmunoassay for vancomycin.

Authors:  K L Fong; D H Ho; L Bogerd; T Pan; N S Brown; L Gentry; G P Bodey
Journal:  Antimicrob Agents Chemother       Date:  1981-01       Impact factor: 5.191

Review 6.  Clinical pharmacokinetics of vancomycin.

Authors:  G R Matzke; G G Zhanel; D R Guay
Journal:  Clin Pharmacokinet       Date:  1986 Jul-Aug       Impact factor: 6.447

7.  Comparison of vancomycin disposition in rats with normal and abnormal renal functions.

Authors:  M S Engineer; D H Ho; G P Bodey
Journal:  Antimicrob Agents Chemother       Date:  1981-12       Impact factor: 5.191
  7 in total

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