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Literature DB >> 5497802

Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart.

Abstract

Various steroids (17-beta-oestradiol, corticosterone, deoxycorticosterone, progesterone, testosterone and androsterone) produced a dose-dependent inhibition of the uptake of (3)H-noradrenaline by the Uptake(2) mechanism in the isolated perfused heart. It is suggested that these results may explain the potentiating effects of such steroids on the responses of vascular smooth muscle to catecholamines.

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Year: 1970 PMID： 5497802 PMCID： PMC1703119 DOI： 10.1111/j.1476-5381.1970.tb10637.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

5 in total

1. A UNIFIED THEORY OF GLUCOCORTICOID ACTION.

Authors: R W SCHAYER
Journal: Perspect Biol Med Date: 1964 Impact factor: 1.416

2. The influence of the adrenal cortex on behavior of terminal vascular bed.

Authors: B W ZWEIFACH; E SHORR; M M BLACK
Journal: Ann N Y Acad Sci Date: 1953-07-17 Impact factor: 5.691

3. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta.

Authors: S Kalsner
Journal: Circ Res Date: 1969-03 Impact factor: 17.367

4. The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart.

Authors: S L Lightman; L L Iversen
Journal: Br J Pharmacol Date: 1969-11 Impact factor: 8.739

5. Steroid potentiation of responses to sympathomimetic amines in aortic strips.

Authors: S Kalsner
Journal: Br J Pharmacol Date: 1969-07 Impact factor: 8.739

5 in total

92 in total

1. Pituitary-adrenal dynamics after ACTH-secreting pituitary tumor resection in patients receiving no steroids post-operatively.

Authors: F R Pimentel-Filho; M E R Silva; K C Nogueira; K Berger; A Cukiert; B Liberman
Journal: J Endocrinol Invest Date: 2005-06 Impact factor: 4.256

2. Effect of isoprenaline on noradrenaline release from sympathetic neurones in rabbit isolated pulmonary artery.

Authors: O A Nedergaard
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1987-08 Impact factor: 3.000

3. The influence of amine metabolizing enzymes on the pharmacology of tyramine in the isolated perfused mesenteric arterial bed of the rat.

Authors: J Elliott; B A Callingham; D F Sharman
Journal: Br J Pharmacol Date: 1989-10 Impact factor: 8.739

9. The influence of oestrogen and oestrogen metabolites on the sensitivity of the isolated rabbit aorta to catecholamines.

Authors: S Barone; D Panek; L Bennett; R E Stitzel; R J Head
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1987-05 Impact factor: 3.000

10. The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline.

Authors: T A McCalden; D Bloom; C Rosendorff
Journal: Experientia Date: 1975-10-15

Inhibition of catecholamine Uptake-2 by steroids in the isolated rat heart.

1. A UNIFIED THEORY OF GLUCOCORTICOID ACTION.

2. The influence of the adrenal cortex on behavior of terminal vascular bed.

3. Mechanism of hydrocortisone potentiation of responses to epinephrine and norepinephrine in rabbit aorta.

4. The role of uptake2 in the extraneuronal metabolism of catecholamines in the isolated rat heart.

5. Steroid potentiation of responses to sympathomimetic amines in aortic strips.

1. Pituitary-adrenal dynamics after ACTH-secreting pituitary tumor resection in patients receiving no steroids post-operatively.

2. Effect of isoprenaline on noradrenaline release from sympathetic neurones in rabbit isolated pulmonary artery.

3. The influence of amine metabolizing enzymes on the pharmacology of tyramine in the isolated perfused mesenteric arterial bed of the rat.

4. The effects of hypercholesterolaemic plasma on vascular sensitivity to noradrenaline.

5. The effect of reserpine treatment on the extraneuronal uptake of [3H]-isoprenaline into rat atria.

6. An uptake mechanism for L-noradrenaline in the cat spleen, associated with the nerves but distinct from uptake.

7. The influence of hormonal and neuronal factors on rat heart adrenoceptors.

8. Inhibition of catecholamine uptake in the isolated rat heart by haloalkylamines related to phenoxybenzamine.

9. The influence of oestrogen and oestrogen metabolites on the sensitivity of the isolated rabbit aorta to catecholamines.

10. The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline.