Literature DB >> 5497801

Inotropic effects of thyroxine and related compounds on guinea-pig left atria in vitro.

J R Baird, B A Spilker.   

Abstract

Triiodothyronine, diiodothyronine and diiodotyrosine have positive inotropic activity on normal guinea-pig left atria in vitro. The increases produced by triiodothyronine and diiodothyronine are small but their detection shows that the inotropic responses to these agents can be studied in vitro. Thyroxine, thyronine and monoiodotyrosine are inactive. Reserpine pre-treatment reduces the inotropic effect of diiodotyrosine but does not reduce those of triiodothyronine and diiodothyronine.

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Year:  1970        PMID: 5497801      PMCID: PMC1703112          DOI: 10.1111/j.1476-5381.1970.tb10636.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN: 0007-1188            Impact factor:   8.739


  4 in total

1.  Effects of heart failure, ventricular hypertrophy, and alterations in the thyroid state on the contractility of isolated cardiac muscle.

Authors:  E Braunwald; E H Sonnenblick; J F Spann; R A Buccino
Journal:  Ann N Y Acad Sci       Date:  1969-01-31       Impact factor: 5.691

2.  Left ventricular myocardial contractile response to aortic constriction in the hyperthyroid guinea pig.

Authors:  M J Goodkind
Journal:  Circ Res       Date:  1968-05       Impact factor: 17.367

3.  Influence of the thyroid state on the intrinsic contractile properties and energy stores of the myocardium.

Authors:  R A Buccino; J F Spann; P E Pool; E H Sonnenblick; E Braunwald
Journal:  J Clin Invest       Date:  1967-10       Impact factor: 14.808

4.  Cardiac failure in the dog as a consequence of exogenous hyperthyroidism.

Authors:  D Piatnek-Leunissen; R E Olson
Journal:  Circ Res       Date:  1967-02       Impact factor: 17.367

  4 in total
  1 in total

1.  Studies of isolated fetal mouse hearts in organ culture. Evidence for a direct effect of triiodothyronine in enhancing cardiac responsiveness to norepinephrine.

Authors:  K Wildenthal
Journal:  J Clin Invest       Date:  1972-10       Impact factor: 14.808

  1 in total

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