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Literature DB >> 5497799

Uptake of dopamine by platelets in vivo.

Abstract

Circulating platelets of cats infused with (14)C-dopamine take up the amine against a concentration gradient, with maximal concentration occurring 10 min after infusion. 58%, of the platelet-bound radioactive dopamine was localized in a subcellular fraction rich in 5-hydroxytryptamine (5-HT) storage organelles. The results support earlier work with human platelets showing in vitro dopamine uptake by normal platelets, and in vivo accumulation in parkinsonian patients treated with L-dopa.

Entities: Chemical Disease Species

Mesh：

Substances：
Carbon Isotopes

Year: 1970 PMID： 5497799 PMCID： PMC1703201 DOI： 10.1111/j.1476-5381.1970.tb10634.x

Source DB: PubMed Journal: Br J Pharmacol ISSN： 0007-1188 Impact factor: 8.739

2 in total

1. Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo.

Authors: D S Robinson; W Lovenberg; H Keiser; A Sjoerdsma
Journal: Biochem Pharmacol Date: 1968-01 Impact factor: 5.858

2. Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA.

Authors: D J Boullin; R A O'Brien
Journal: Br J Pharmacol Date: 1970-08 Impact factor: 8.739

2 in total

5 in total

1. Effects of intracranial dopamine perfusion: behavioural arousal and reversal of cerebral arterial spasm following surgery for clipping of ruptured cerebral aneurysms.

Authors: D J Boullin; C B Adams; J Mohan; A R Green; T M Hunt; G H du Boulay; A T Rogers
Journal: Proc R Soc Med Date: 1977

5. Tissue-Specificity of Antibodies Raised Against TrkB and p75^NTR Receptors; Implications for Platelets as Models of Neurodegenerative Diseases.

Authors: Samuel Fleury; Imane Boukhatem; Jessica Le Blanc; Mélanie Welman; Marie Lordkipanidzé
Journal: Front Immunol Date: 2021-02-11 Impact factor: 7.561

5 in total

Uptake of dopamine by platelets in vivo.

1. Effects of drugs on human blood platelet and plasma amine oxidase activity in vitro and in vivo.

2. Accumulation of dopamine by blood platelets from normal subjects and parkinsonian patients under treatment with L-DOPA.

1. Effects of intracranial dopamine perfusion: behavioural arousal and reversal of cerebral arterial spasm following surgery for clipping of ruptured cerebral aneurysms.

2. Human blood platelets as cellular models for investigation of membrane active drugs: beta-adrenergic blocking agents.

3. Evaluation of the uptake of various amines into storage vesicles of intact human platelets.

4. Identification of a dopamine-binding protein on the membrane of the human platelet.

5. Tissue-Specificity of Antibodies Raised Against TrkB and p75^NTR Receptors; Implications for Platelets as Models of Neurodegenerative Diseases.